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anti-Human Insulin Receptor Antibodies:
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Mouse (Murine) Monoclonal Insulin Receptor Primary Antibody for IF, IP - ABIN967752
Ebina, Ellis, Jarnagin, Edery, Graf, Clauser, Ou, Masiarz, Kan, Goldfine: The human insulin receptor cDNA: the structural basis for hormone-activated transmembrane signalling. in Cell 1985
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Mouse (Murine) Monoclonal Insulin Receptor Primary Antibody for IF, IP - ABIN967753
Frattali, Treadway, Pessin: Insulin/IGF-1 hybrid receptors: implications for the dominant-negative phenotype in syndromes of insulin resistance. in Journal of cellular biochemistry 1992
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Human Polyclonal Insulin Receptor Primary Antibody for IF, WB - ABIN968448
Kasus-Jacobi, Béréziat, Perdereau, Girard, Burnol: Evidence for an interaction between the insulin receptor and Grb7. A role for two of its binding domains, PIR and SH2. in Oncogene 2000
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Rat (Rattus) Polyclonal Insulin Receptor Primary Antibody for IF, WB - ABIN968449
Lu, Guidotti: Identification of the cysteine residues involved in the class I disulfide bonds of the human insulin receptor: properties of insulin receptor monomers. in Molecular biology of the cell 1997
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Human Polyclonal Insulin Receptor Primary Antibody for CyTOF, FACS - ABIN4900627
Purushothaman, Babitz, Sanderson: Heparanase enhances the insulin receptor signaling pathway to activate extracellular signal-regulated kinase in multiple myeloma. in The Journal of biological chemistry 2012
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Human Monoclonal Insulin Receptor Primary Antibody for FACS - ABIN2689096
Soos, OBrien, Brindle, Stigter, Okamoto, Whittaker, Siddle: Monoclonal antibodies to the insulin receptor mimic metabolic effects of insulin but do not stimulate receptor autophosphorylation in transfected NIH 3T3 fibroblasts. in Proceedings of the National Academy of Sciences of the United States of America 1989
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Human Polyclonal Insulin Receptor Primary Antibody for IHC (p) - ABIN2479300
Jamner, Shapiro, Goldstein, Hug: Ambulatory blood pressure and heart rate in paramedics: effects of cynical hostility and defensiveness. in Psychosomatic medicine 1991
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Human Polyclonal Insulin Receptor Primary Antibody for IF (p), IHC (p) - ABIN671841
Bai, Chen, Liu, Tian, Zhou, Liu, Fang, Chen: Effects of water extract and crude polysaccharides from Liriope spicata var. prolifera on InsR/IRS-1/PI3K pathway and glucose metabolism in mice. in Journal of ethnopharmacology 2009
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Human Polyclonal Insulin Receptor Primary Antibody for WB - ABIN4226906
Cappuzzo, Toschi, Tallini, Ceresoli, Domenichini, Bartolini, Finocchiaro, Magrini, Metro, Cancellieri, Trisolini, Crino, Bunn, Santoro, Franklin, Varella-Garcia, Hirsch: Insulin-like growth factor receptor 1 (IGFR-1) is significantly associated with longer survival in non-small-cell lung cancer patients treated with gefitinib. in Annals of oncology : official journal of the European Society for Medical Oncology 2006
Human Polyclonal Insulin Receptor Primary Antibody for FACS - ABIN4897181
Saiya-Cork, Collins, Parkin, Ouillette, Kuizon, Kujawski, Erba, Campagnaro, Shedden, Kaminski, Malek: A pathobiological role of the insulin receptor in chronic lymphocytic leukemia. in Clinical cancer research : an official journal of the American Association for Cancer Research 2011
The gained results are observed not only the unbinding mechanism of IRK (show KCNJ12 Antibodies)-PTP1B (show PTPN1 Antibodies) complexes came from pulling force profile, number of hydrogen bonds, and interaction energy between IRK (show KCNJ12 Antibodies) and PTP1Bs but also described PTP1B's point mutations could variably change its binding affinity towards IRK (show KCNJ12 Antibodies).
The data in this paper demonstrate that IR knockdown in primary tumors partially reverses the growth-promoting effects of hyperinsulinemia as well as highlighting the importance of the insulin receptor signaling pathway in cancer progression, and more specifically in epithelial-mesenchymal transition.
INSR rs2252673 and rs3745546 polymorphisms were associated with sensitivity to platinum-based chemotherapy in epithelial ovarian cancer patients and rs2252673 polymorphism may be an independent risk factor for EOC prognosis.
The IGF1R (show IGF1R Antibodies) purified in n-dodecyl-beta-D-maltoside showed ligand-stimulated autophosphorylation and kinase activity, suggesting an intact transmembrane signaling mechanism.
Signaling via the insulin (INS (show INS Antibodies)) and insulin-like growth factor 1 (IGF1 (show IGF1 Antibodies)) receptors (INSR and IGF1R (show IGF1R Antibodies)) regulate basal cell (BC) differentiation into ciliated cells.
High INSR expression is associated with drug Resistance in Gastrointestinal Stromal Tumors.
the above data indicate a direct role for IR expression as a determinant of PT-gluconeogenesis. Thus reduced insulin (show INS Antibodies) signaling of the proximal tubule may contribute to hyperglycemia in the metabolic syndrome via elevated gluconeogenesis.
Activation of D4 receptor inhibits insulin receptor expression in RPT cells from WKY rats. The aberrant inhibition of D4 receptor on insulin receptor expression and effect might be involved in the pathogenesis of essential hypertension.
The HIR (show KCNJ4 Antibodies) MAb binds the insulin receptor on the BBB (show ALMS1 Antibodies).
data indicate that post-receptor signalling abnormalities might contribute to Myotonic dystrophy insulin (show INS Antibodies) resistance regardless the alteration of INSR splicing.
long-term hepatic expression of IRA could be a promising therapeutic approach for the treatment of type 2 diabetes mellitus.
the overlap of IR and IGF1R (show IGF1R Antibodies) signaling is critical to the regulation of muscle protein turnover, and this regulation depends on suppression of FoxO (show FOXO3 Antibodies)-regulated, autophagy-mediated protein degradation
These data reveal a critical pathophysiological role for INSR Thr1160 phosphorylation and provide further mechanistic links between PKCepsilon (show PRKCE Antibodies) and INSR in mediating Nonalcoholic fatty liver disease -induced hepatic insulin (show INS Antibodies) resistance.
Insr was downregulated in the arcuate nucleus of type 2 diabetic mice.
Mice lacking the insulin receptor in AgRP (show AGRP Antibodies) neurons (AgRP (show AGRP Antibodies) IR KO) exhibited impaired hepatic insulin (show INS Antibodies) action because the ability of insulin (show INS Antibodies) to suppress hepatic glucose production (hGP) was reduced, but the ability of insulin (show INS Antibodies) to suppress lipolysis was unaltered. To the contrary, in POMC (show POMC Antibodies) IR KO mice, insulin (show INS Antibodies) lowered hGP but failed to suppress adipose tissue lipolysis.
Intracellular retention of the insulin receptor is caused by elevated amounts of alpha-taxilin (show TXLNA Antibodies), a free syntaxin binding protein, in HBV expressing hepatocytes preventing proper targeting of the insulin receptor to the cell surface.
Results found that glioblastoma tumors resistant to PDGFR (show PDGFRB Antibodies) inhibition required the expression and activation of the insulin receptor (IR)/insulin (show INS Antibodies) growth-like factor receptor (IGF1R (show IGF1R Antibodies)) for tumor cell proliferation and survival.
The IR in the intestinal epithelium plays important roles in intestinal gene expression, glucose uptake, and GIP (show GIP Antibodies) production, which may contribute to pathophysiological changes in individuals with diabetes, metabolic syndrome, and other insulin (show INS Antibodies)-resistant states.
In conclusion, we have identified that ARL15 acts as an insulin (show INS Antibodies)-sensitizing effector molecule to upregulate the phosphorylation of members of the canonical IR/IRS1 (show IRS1 Antibodies)/PDPK1 (show PDPK1 Antibodies)/AKT (show AKT1 Antibodies) insulin (show INS Antibodies) pathway by interacting with its GAP ASAP2 (show ASAP2 Antibodies) and activating PDPK1 (show PDPK1 Antibodies). This research may provide new insights into GTPase (show RACGAP1 Antibodies)-mediated insulin (show INS Antibodies) signalling regulation and facilitate the development of new pharmacotherapeutic targets for insulin (show INS Antibodies) sensitizati
it was demonstrated that InR was expressed in follicular cells and that its expression in corpus allatum and follicular cells of Drosophila females was stage-specific, i.e., the expression intensity in young females greatly exceeded that in mature individuals.
INR signaling promotes glial phagocytic clearance of degenerating axons through regulation of Draper.
These results demonstrate that Dock selectively enhances the PTP61Fm-mediated attenuation of InR signalling and underscores the specificity of PTPs and the importance of adaptor proteins in regulating PTP function in vivo.
Mactosylceramide, an early product in GSL (show CTSA Antibodies) biosynthesis, prevents inappropriate activation of insulin (show INS Antibodies) and fibroblast growth factor receptors in Drosophila glial cells and hypertrophy.
Results show that lifespan and behavioral senescence are independently regulated by the Drosophila insulin receptor.
Study shows that the increase in the dopamine level in D. melanogaster females with the InR gene knockdown in corpus allatum ensures their increased resistance to starvation-induced stress
results indicate that the Drosophila insulin-like peptide system is a crucial regulator of sleep
This study has shown for the first time that suppression of InR expression in VNC leads to a rise in the survival of flies under conditions of toxic stress.
The combined activities of Stit and InR in ectodermal epithelial tissues provide an RTK-mediated, two-tiered reaction threshold to varying nutritional conditions that promote epithelial organ growth even at low levels of InR signaling.
InR, but not Tor, signaling non-autonomously promotes primordial germ cell differentiation.
studied by RT reverse-transcription PCR, whether there are differences in the abundance of mRNA coding for IGF-I (show IGF1 Antibodies), IGF-2, IGFBP-2 (show IGFBP2 Antibodies), IGFBP-3 (show IGFBP3 Antibodies), IGF-1R (show IGF1R Antibodies), IGF-2R, GHR (show GHR Antibodies), and InsR in compartmentalized layers of jejunum and ileum of 5-d-old calves fed colostrum
insulin receptor and phosphoinositide 3-kinase localize to detergent-resistant membrane rafts of rod photoreceptor outer segments
FSH (show BRD2 Antibodies), but not E2, stimulated the expression of IR and GHR (show GHR Antibodies) genes during follicular development.
Data conclude that insulin (show INS Antibodies) and IGF-I (show IGF1 Antibodies) receptors differentially mediate the production of adhesion molecules by ECs and monocyte adhesion onto the vascular endothelium in response to the hyperinsulinemic state.
After removal of the precursor signal peptide, the insulin receptor precursor is post-translationally cleaved into two chains (alpha and beta) that are covalently linked. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. Two transcript variants encoding different isoforms have been found for this gene.
, drosophila insulin receptor
, insulin receptor
, insulin receptor homolog
, insulin receptor homologue
, insulin-like receptor
, insulin receptor tyrosine kinase
, tyrosine kinase
, insulin receptor-like
, insulin receptor, beta-subunit