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anti-Human Insulin Receptor Antibodies:
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Human Polyclonal Insulin Receptor Primary Antibody for DB, ELISA - ABIN548700
McGettrick, Feener, Kahn: Human insulin receptor substrate-1 (IRS-1) polymorphism G972R causes IRS-1 to associate with the insulin receptor and inhibit receptor autophosphorylation. in The Journal of biological chemistry 2005
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Human Polyclonal Insulin Receptor Primary Antibody for IHC (p) - ABIN2479300
Jamner, Shapiro, Goldstein, Hug: Ambulatory blood pressure and heart rate in paramedics: effects of cynical hostility and defensiveness. in Psychosomatic medicine 1991
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Human Polyclonal Insulin Receptor Primary Antibody for CyTOF, FACS - ABIN4900627
Purushothaman, Babitz, Sanderson: Heparanase enhances the insulin receptor signaling pathway to activate extracellular signal-regulated kinase in multiple myeloma. in The Journal of biological chemistry 2012
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Human Monoclonal Insulin Receptor Primary Antibody for FACS - ABIN2689096
Soos, OBrien, Brindle, Stigter, Okamoto, Whittaker, Siddle: Monoclonal antibodies to the insulin receptor mimic metabolic effects of insulin but do not stimulate receptor autophosphorylation in transfected NIH 3T3 fibroblasts. in Proceedings of the National Academy of Sciences of the United States of America 1989
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Human Polyclonal Insulin Receptor Primary Antibody for IHC (p), ELISA - ABIN6923120
George, Johansen, Soos, Mortensen, Gammeltoft, Saudek, Siddle, Hansen, ORahilly: Deletion of V335 from the L2 domain of the insulin receptor results in a conformationally abnormal receptor that is unable to bind insulin and causes Donohue's syndrome in a human subject. in Endocrinology 2003
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Human Polyclonal Insulin Receptor Primary Antibody for IF (p), IHC (p) - ABIN671841
Bai, Chen, Liu, Tian, Zhou, Liu, Fang, Chen: Effects of water extract and crude polysaccharides from Liriope spicata var. prolifera on InsR/IRS-1/PI3K pathway and glucose metabolism in mice. in Journal of ethnopharmacology 2009
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Human Polyclonal Insulin Receptor Primary Antibody for FACS - ABIN4897181
Saiya-Cork, Collins, Parkin, Ouillette, Kuizon, Kujawski, Erba, Campagnaro, Shedden, Kaminski, Malek: A pathobiological role of the insulin receptor in chronic lymphocytic leukemia. in Clinical cancer research : an official journal of the American Association for Cancer Research 2011
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Human Polyclonal Insulin Receptor Primary Antibody for WB - ABIN3043142
Wang, Sun, Li, Dong, Li, Zhao: Resveratrol attenuates intermittent hypoxia-induced insulin resistance in rats: involvement of Sirtuin 1 and the phosphatidylinositol-4,5-bisphosphate 3-kinase/AKT pathway. in Molecular medicine reports 2014
Human Polyclonal Insulin Receptor Primary Antibody for WB - ABIN4226906
Cappuzzo, Toschi, Tallini, Ceresoli, Domenichini, Bartolini, Finocchiaro, Magrini, Metro, Cancellieri, Trisolini, Crino, Bunn, Santoro, Franklin, Varella-Garcia, Hirsch: Insulin-like growth factor receptor 1 (IGFR-1) is significantly associated with longer survival in non-small-cell lung cancer patients treated with gefitinib. in Annals of oncology : official journal of the European Society for Medical Oncology 2006
Decreased IR levels in adipose tissue may be a relevant pathogenic factor in gestational diabetes mellitus, affecting materno-fetal metabolism
lnc-INSR might promote immune suppression.
To escape EGFR-TKI treatment, CCA tumor cells develop an adaptive mechanism by undergoing an IR/IGF1R-dependent phenotypic switch, involving a contribution of stromal cells.
The authors show for the first time that the two insulin receptor isoforms, designated IR/A and IR/B, are both expressed in neurons in the adult human brain.
We additionally show, using preclinical mouse as well as patient data, that treatment with the inhibitor sunitinib significantly reduces the expression of INSR-A. CONCLUSIONS: The current study underscores the oncogenic impact of INSR and suggests that targeting the INSR-A isoform should be considered in therapeutic settings.
overall significant differences were found in genotype distribution and allele frequency for SNP rs2229431 of INSR in exon 13, and tendencies towards overall significant differences were found for SNP rs12610022 in intron 13
Partial lipodystrophy and Type A insulin resistance syndrome due to a novel heterozygous missense mutation in the insulin receptor gene in a mother and daughter pair.
These findings uncover a biased GPCR agonist-induced IR transactivation signaling axis, mediated by Neu1 sialidase and the modification of insulin receptor glycosylation.
insulin binding to the dimeric receptor converts its ectodomain from an inverted U-shaped conformation to a T-shaped conformation.
Modifications of Site 1 of the insulin are sufficient to change the binding to for both insulin receptor and insulin-like growth factor 1 receptor.
the miRNA binding site polymorphism rs1366600 located at the 3'-UTR region of the INSR gene is associated with increased risk of T2DM in Bangladeshi individuals
The role for PGRMC1 maintaining plasma membrane pools of the receptor, modulating IR signaling and function.
Four heterozygous missense mutations within the beta-subunit of insulin receptor (INSR) were detected: Gly1146Arg, Arg1158Trp, Arg1201Trp, and Arg1201Pro mutation in Type A insulin resistance syndrome.
There was a significant upregulation of insulin (INS) and INS Receptor expression levels in Alzheimer's disease both prodromal and fully symptomatic, as compared with controls, but not in mild cognitive impairment subjects.
The structural refinement of the antagonist once conjugated to insulin provided a set of partial agonists exhibiting between 25 and 70% of the maximal agonism of native insulin at the two insulin receptor isoforms, with only slight differences in inherent potency
Cav-2beta isoform yielded by alternative translation initiation desensitizes insulin receptor (IR) via dephosphorylation by PTP1B, and subsequent endocytosis and lysosomal degradation of IR, causing insulin resistance.
They retained the main IGF-1R-related properties, but the hormones with His49 in IGF-1 and His48 in IGF-2 showed significantly higher affinities for IR-A and for IR-B, being the strongest IGF-1- and IGF-2-like binders of these receptors ever reported.
MARCH1 ubiquitinates INSR to decrease cell surface INSR levels, but unlike other INSR ubiquitin ligases, MARCH1 acts in the basal state rather than after insulin stimulation.
single-particle cryo-electron microscopy reconstructions of the 1:2 (4.3 A) and 1:1 (7.4 A) complexes of the insulin receptor ECD dimer with insulin
we aim to provide an overview of the physiological and pathophysiological roles of the IR within metabolic syndrome and its related pathologies, including cardiovascular health, gut microflora composition, gastrointestinal tract functioning, polycystic ovarian syndrome, pancreatic cancer, and neurodegenerative disorders
Mice with selective deletion of Insr in LepR expressing hypothalamic neurons have increased fat mass, increased food intake, locomotor activity, carbon dioxide production, and respiratory exchange rate, reduced fat oxidation, increased glucose oxidation, overall reduced basal glucose levels.
We additionally show, using preclinical mouse as well as patient data, that treatment with the inhibitor sunitinib significantly reduces the expression of INSR-A.
Insulin receptor signaling regulates renal collecting duct and intercalated cell antibacterial defenses.
IRA, but not IRB, expression induced increased glucose uptake in the liver and muscle, improving insulin tolerance.
These in vitro data indicate that peripheral insulin must reach the brain parenchyma through alternative pathways rather than crossing the blood-brain barrier via INSR mediated transcytosis.
Insulin and leptin do not exert redundant control of dopamine neuron-mediated modulation of energy balance. Furthermore, neither leptin nor insulin plays a critical role in the modulation of dopamine neurons regarding hedonic feeding behavior or anxiety-related behavior.
These data show that restoration of endothelial insulin receptor expression alone is sufficient to prevent the vascular dysfunction caused by systemically reduced insulin signaling.
Cell-lineage tracing revealed progenitor Leydig cell enrichment is secondary to Insr and Igf1r deletion in differentiated adult Leydig cell , suggesting a feedback mechanism between cells at different steps of differentiation.
Insulin receptor knock-out mice display elevated serum insulin levels, glucose intolerance, and increased insulin content in the islets of Langerhans of the pancreas.
Loss of Endothelial IR Impairs Barrier Function in the Brain.
diabetic gastroparesis was an aggressive process due to the successive damages of myenteric cholinergic neurones and ICC by impairing the insulin/InsR and IGF-1/IGF-1R signaling. Insulin therapy in the early stage may delay diabetic gastroparesis
in beta cells, INSR-B has a protective role, while INSR-A expression sensitizes beta cells to programmed cell death.
we show that glucagon receptor (GCGR) inhibition with a monoclonal antibody normalized blood glucose and beta-hydroxybutyrate levels. Insulin receptor antagonism increased pancreatic beta-cell mass threefold. Normalization of blood glucose levels with GCGR-blocking antibody unexpectedly doubled beta-cell mass relative to that observed with S961 alone and 5.8-fold over control
Data (including data from studies in knockout mice) suggest double knockout (DKO) mice lacking Insr and Igf1r exhibit obesity with insulin resistance and increased adiposity; on high-fat diet, DKO mice exhibit metabolic syndrome. (Insr = insulin receptor; Igf1r = insulin-like growth factor I receptor)
The data in this paper demonstrate that IR knockdown in primary tumors partially reverses the growth-promoting effects of hyperinsulinemia as well as highlighting the importance of the insulin receptor signaling pathway in cancer progression, and more specifically in epithelial-mesenchymal transition.
long-term hepatic expression of IRA could be a promising therapeutic approach for the treatment of type 2 diabetes mellitus.
the overlap of IR and IGF1R signaling is critical to the regulation of muscle protein turnover, and this regulation depends on suppression of FoxO-regulated, autophagy-mediated protein degradation
These data reveal a critical pathophysiological role for INSR Thr1160 phosphorylation and provide further mechanistic links between PKCepsilon and INSR in mediating Nonalcoholic fatty liver disease -induced hepatic insulin resistance.
Insr was downregulated in the arcuate nucleus of type 2 diabetic mice.
Mice lacking the insulin receptor in AgRP neurons (AgRP IR KO) exhibited impaired hepatic insulin action because the ability of insulin to suppress hepatic glucose production (hGP) was reduced, but the ability of insulin to suppress lipolysis was unaltered. To the contrary, in POMC IR KO mice, insulin lowered hGP but failed to suppress adipose tissue lipolysis.
Rab6 promotes localization of the insulin receptor to the plasma membrane.
Hsp83 functions upstream of the InR/PI3K/Akt pathway during neural stem cell reactivation.
Immunosenescence in Drosophila suggests its possible mechanisms that involve changes in insulin/IGF-1 signaling. (Review)
a sensory neuron-specific function of InR regulates the persistence of injury-associated hypersensitivity.
This FMRP activity is mediated solely via a second conserved RNA-binding protein, LIN-28, known to boost insulin signaling in stem cells. Via LIN-28, FMRP controls progenitor cell behavior by post-transcriptionally repressing the level of insulin receptor (InR).
Impairment of insulin signalling in the mushroom body neurons, a structure involved in associative learning, impairs feeding behaviour in the Drosophila larva.[Insulin]
it was demonstrated that InR was expressed in follicular cells and that its expression in corpus allatum and follicular cells of Drosophila females was stage-specific, i.e., the expression intensity in young females greatly exceeded that in mature individuals.
INR signaling promotes glial phagocytic clearance of degenerating axons through regulation of Draper.
These results demonstrate that Dock selectively enhances the PTP61Fm-mediated attenuation of InR signalling and underscores the specificity of PTPs and the importance of adaptor proteins in regulating PTP function in vivo.
Mactosylceramide, an early product in GSL biosynthesis, prevents inappropriate activation of insulin and fibroblast growth factor receptors in Drosophila glial cells and hypertrophy.
Results show that lifespan and behavioral senescence are independently regulated by the Drosophila insulin receptor.
Study shows that the increase in the dopamine level in D. melanogaster females with the InR gene knockdown in corpus allatum ensures their increased resistance to starvation-induced stress
results indicate that the Drosophila insulin-like peptide system is a crucial regulator of sleep
This study has shown for the first time that suppression of InR expression in VNC leads to a rise in the survival of flies under conditions of toxic stress.
The combined activities of Stit and InR in ectodermal epithelial tissues provide an RTK-mediated, two-tiered reaction threshold to varying nutritional conditions that promote epithelial organ growth even at low levels of InR signaling.
InR, but not Tor, signaling non-autonomously promotes primordial germ cell differentiation.
Drosophila poly suggests a novel role for the Elongator complex in insulin receptor-target of rapamycin signalling.
Mutations in the D. melanogaster Insulin Receptor (InR) alter SGP cell number but not ovarian morphogenesis
Concerted control of gliogenesis by InR/TOR and FGF signalling in the Drosophila post-embryonic brain
The phospholipase C-gamma (PLC-gamma) encoded by small wing (sl) acts as such a link between growth and patterning/differentiation by modulating some MAPK outputs once activated by the insulin pathway.
The expression of IR mRNA in the liver of ketotic dairy cows was higher than in cows with fatty liver, but in both disease groups the expression was substantially lower than that in normal liver.
studied by RT reverse-transcription PCR, whether there are differences in the abundance of mRNA coding for IGF-I, IGF-2, IGFBP-2, IGFBP-3, IGF-1R, IGF-2R, GHR, and InsR in compartmentalized layers of jejunum and ileum of 5-d-old calves fed colostrum
insulin receptor and phosphoinositide 3-kinase localize to detergent-resistant membrane rafts of rod photoreceptor outer segments
FSH, but not E2, stimulated the expression of IR and GHR genes during follicular development.
Data conclude that insulin and IGF-I receptors differentially mediate the production of adhesion molecules by ECs and monocyte adhesion onto the vascular endothelium in response to the hyperinsulinemic state.
After removal of the precursor signal peptide, the insulin receptor precursor is post-translationally cleaved into two chains (alpha and beta) that are covalently linked. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. Two transcript variants encoding different isoforms have been found for this gene.
, drosophila insulin receptor
, insulin receptor
, insulin receptor homolog
, insulin receptor homologue
, insulin-like receptor
, insulin receptor tyrosine kinase
, tyrosine kinase
, insulin receptor-like
, insulin receptor, beta-subunit