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Human Monoclonal Insulin Receptor Primary Antibody for FACS - ABIN2689096
Soos, OBrien, Brindle, Stigter, Okamoto, Whittaker, Siddle: Monoclonal antibodies to the insulin receptor mimic metabolic effects of insulin but do not stimulate receptor autophosphorylation in transfected NIH 3T3 fibroblasts. in Proceedings of the National Academy of Sciences of the United States of America 1989
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Human Polyclonal Insulin Receptor Primary Antibody for IHC (p) - ABIN2479300
Jamner, Shapiro, Goldstein, Hug: Ambulatory blood pressure and heart rate in paramedics: effects of cynical hostility and defensiveness. in Psychosomatic medicine 1991
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Human Polyclonal Insulin Receptor Primary Antibody for CyTOF, FACS - ABIN4900627
Purushothaman, Babitz, Sanderson: Heparanase enhances the insulin receptor signaling pathway to activate extracellular signal-regulated kinase in multiple myeloma. in The Journal of biological chemistry 2012
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Human Polyclonal Insulin Receptor Primary Antibody for IF (p), IHC (p) - ABIN671841
Bai, Chen, Liu, Tian, Zhou, Liu, Fang, Chen: Effects of water extract and crude polysaccharides from Liriope spicata var. prolifera on InsR/IRS-1/PI3K pathway and glucose metabolism in mice. in Journal of ethnopharmacology 2009
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Human Polyclonal Insulin Receptor Primary Antibody for FACS - ABIN4897181
Saiya-Cork, Collins, Parkin, Ouillette, Kuizon, Kujawski, Erba, Campagnaro, Shedden, Kaminski, Malek: A pathobiological role of the insulin receptor in chronic lymphocytic leukemia. in Clinical cancer research : an official journal of the American Association for Cancer Research 2011
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Human Polyclonal Insulin Receptor Primary Antibody for FACS - ABIN4897184
Mancini, Gariboldi, Taiana, Bonzi, Craparotta, Pagin, Monti: Co-targeting the IGF system and HIF-1 inhibits migration and invasion by (triple-negative) breast cancer cells. in British journal of cancer 2014
Human Polyclonal Insulin Receptor Primary Antibody for BP, Neut - ABIN5665635
Moteki, Shimamura, Kimura, Ogihara: Signal transduction pathway for L-ascorbic acid- and L-ascorbic acid 2-glucoside-induced DNA synthesis and cell proliferation in primary cultures of adult rat hepatocytes. in European journal of pharmacology 2012
Human Polyclonal Insulin Receptor Primary Antibody for WB - ABIN4226906
Cappuzzo, Toschi, Tallini, Ceresoli, Domenichini, Bartolini, Finocchiaro, Magrini, Metro, Cancellieri, Trisolini, Crino, Bunn, Santoro, Franklin, Varella-Garcia, Hirsch: Insulin-like growth factor receptor 1 (IGFR-1) is significantly associated with longer survival in non-small-cell lung cancer patients treated with gefitinib. in Annals of oncology : official journal of the European Society for Medical Oncology 2006
the mechanism by which insulin (show INS Antibodies) induces IR translocation to the cell nucleus, was examined.
We conclude that the crosstalk between angiotensin AT1 receptor (show AGTRAP Antibodies) and insulin receptor signaling shows a high degree of specificity, and involves Galphaq (show GNAQ Antibodies) protein, and activation of distinct kinases. Thus, the BRET (show DNER Antibodies)(2) technique can be used as a platform for studying molecular mechanisms of crosstalk between insulin receptor and 7TM receptors.
INSR rs1051690 SNP is associated with increased risk of gastric cancer, while polymorphisms in IL12B (show IL12B Antibodies), CCND1 (show CCND1 Antibodies) and IL10 (show IL10 Antibodies) genes are not linked with the presence of gastric cancer
Findings demonstrate that, in human breast cancer cells, DDR1 (show DDR1 Antibodies) regulates IR expression and ligand dependent biological actions. This novel functional crosstalk is likely clinically relevant.
in beta cells, INSR-B has a protective role, while INSR-A expression sensitizes beta cells to programmed cell death.
These results support the hypothesis that INSR gene expression in different areas of Alzheimer's patient's brains.
In endocrine-sensitive breast cancer cells, insulin (show INS Antibodies) was not growth stimulatory, likely due to the presence of hybrid InsR/IGF1R (show IGF1R Antibodies), which has high affinity for IGF-I (show IGF1 Antibodies), but not insulin (show INS Antibodies). Combination inhibition of InsR and IGF1R (show IGF1R Antibodies) showed complete suppression of the system in endocrine-sensitive breast cancer cells
Report complex relationships between individual tumor-specific expression of IGF1R (show IGF1R Antibodies)/pIGF1R and InsR/pInsR, response endocrine treatment and breast cancer prognosis.
analysis of compounds that cause IGF-1Rbeta but not Insulin Receptor degradation specifically in tumor cells with no effects seen in normal diploid fibroblasts
The gained results are observed not only the unbinding mechanism of IRK (show KCNJ12 Antibodies)-PTP1B (show PTPN1 Antibodies) complexes came from pulling force profile, number of hydrogen bonds, and interaction energy between IRK (show KCNJ12 Antibodies) and PTP1Bs but also described PTP1B's point mutations could variably change its binding affinity towards IRK (show KCNJ12 Antibodies).
diabetic gastroparesis was an aggressive process due to the successive damages of myenteric cholinergic neurones and ICC by impairing the insulin (show INS Antibodies)/InsR and IGF-1 (show IGF1 Antibodies)/IGF-1R (show IGF1R Antibodies) signaling. Insulin (show INS Antibodies) therapy in the early stage may delay diabetic gastroparesis
we show that glucagon receptor (GCGR (show GCGR Antibodies)) inhibition with a monoclonal antibody normalized blood glucose and beta-hydroxybutyrate levels. Insulin receptor antagonism increased pancreatic beta-cell mass threefold. Normalization of blood glucose levels with GCGR (show GCGR Antibodies)-blocking antibody unexpectedly doubled beta-cell mass relative to that observed with S961 alone and 5.8-fold over control
Data (including data from studies in knockout mice) suggest double knockout (DKO) mice lacking Insr and Igf1r (show IGF1R Antibodies) exhibit obesity with insulin (show INS Antibodies) resistance and increased adiposity; on high-fat diet, DKO mice exhibit metabolic syndrome. (Insr = insulin receptor; Igf1r (show IGF1R Antibodies) = insulin-like growth factor I receptor (show IGF1R Antibodies))
The data in this paper demonstrate that IR knockdown in primary tumors partially reverses the growth-promoting effects of hyperinsulinemia as well as highlighting the importance of the insulin receptor signaling pathway in cancer progression, and more specifically in epithelial-mesenchymal transition.
long-term hepatic expression of IRA could be a promising therapeutic approach for the treatment of type 2 diabetes mellitus.
the overlap of IR and IGF1R (show IGF1R Antibodies) signaling is critical to the regulation of muscle protein turnover, and this regulation depends on suppression of FoxO (show FOXO3 Antibodies)-regulated, autophagy-mediated protein degradation
These data reveal a critical pathophysiological role for INSR Thr1160 phosphorylation and provide further mechanistic links between PKCepsilon (show PRKCE Antibodies) and INSR in mediating Nonalcoholic fatty liver disease -induced hepatic insulin (show INS Antibodies) resistance.
Insr was downregulated in the arcuate nucleus of type 2 diabetic mice.
Mice lacking the insulin receptor in AgRP (show AGRP Antibodies) neurons (AgRP (show AGRP Antibodies) IR KO) exhibited impaired hepatic insulin (show INS Antibodies) action because the ability of insulin (show INS Antibodies) to suppress hepatic glucose production (hGP) was reduced, but the ability of insulin (show INS Antibodies) to suppress lipolysis was unaltered. To the contrary, in POMC (show POMC Antibodies) IR KO mice, insulin (show INS Antibodies) lowered hGP but failed to suppress adipose tissue lipolysis.
Impairment of insulin (show INS Antibodies) signalling in the mushroom body neurons, a structure involved in associative learning, impairs feeding behaviour in the Drosophila larva.[Insulin (show INS Antibodies)]
it was demonstrated that InR was expressed in follicular cells and that its expression in corpus allatum and follicular cells of Drosophila females was stage-specific, i.e., the expression intensity in young females greatly exceeded that in mature individuals.
INR signaling promotes glial phagocytic clearance of degenerating axons through regulation of Draper.
These results demonstrate that Dock selectively enhances the PTP61Fm-mediated attenuation of InR signalling and underscores the specificity of PTPs and the importance of adaptor proteins in regulating PTP function in vivo.
Mactosylceramide, an early product in GSL (show CTSA Antibodies) biosynthesis, prevents inappropriate activation of insulin (show INS Antibodies) and fibroblast growth factor receptors in Drosophila glial cells and hypertrophy.
Results show that lifespan and behavioral senescence are independently regulated by the Drosophila insulin receptor.
Study shows that the increase in the dopamine level in D. melanogaster females with the InR gene knockdown in corpus allatum ensures their increased resistance to starvation-induced stress
results indicate that the Drosophila insulin-like peptide system is a crucial regulator of sleep
This study has shown for the first time that suppression of InR expression in VNC leads to a rise in the survival of flies under conditions of toxic stress.
The combined activities of Stit and InR in ectodermal epithelial tissues provide an RTK-mediated, two-tiered reaction threshold to varying nutritional conditions that promote epithelial organ growth even at low levels of InR signaling.
studied by RT reverse-transcription PCR, whether there are differences in the abundance of mRNA coding for IGF-I (show IGF1 Antibodies), IGF-2, IGFBP-2 (show IGFBP2 Antibodies), IGFBP-3 (show IGFBP3 Antibodies), IGF-1R (show IGF1R Antibodies), IGF-2R, GHR (show GHR Antibodies), and InsR in compartmentalized layers of jejunum and ileum of 5-d-old calves fed colostrum
insulin receptor and phosphoinositide 3-kinase localize to detergent-resistant membrane rafts of rod photoreceptor outer segments
FSH (show BRD2 Antibodies), but not E2, stimulated the expression of IR and GHR (show GHR Antibodies) genes during follicular development.
Data conclude that insulin (show INS Antibodies) and IGF-I (show IGF1 Antibodies) receptors differentially mediate the production of adhesion molecules by ECs and monocyte adhesion onto the vascular endothelium in response to the hyperinsulinemic state.
After removal of the precursor signal peptide, the insulin receptor precursor is post-translationally cleaved into two chains (alpha and beta) that are covalently linked. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. Two transcript variants encoding different isoforms have been found for this gene.
, drosophila insulin receptor
, insulin receptor
, insulin receptor homolog
, insulin receptor homologue
, insulin-like receptor
, insulin receptor tyrosine kinase
, tyrosine kinase
, insulin receptor-like
, insulin receptor, beta-subunit