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anti-Rat (Rattus) MAP3K7 Antibodies:
anti-Human MAP3K7 Antibodies:
anti-Mouse (Murine) MAP3K7 Antibodies:
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Rab1 (show RAB1A Antibodies) is regulated by the host in a similar fashion, and that the innate immunity kinase TAK1 and Legionella effectors compete to regulate Rab1 (show RAB1A Antibodies) by switch II modifications during infection.
nMet accelerated HCC (show FAM126A Antibodies) tumorigenesis and metastasis via the activation of TAK1/NF-kappaB (show NFKB1 Antibodies) pathway.
TAK1 protein expression increased in cartilage tissue from spinal tuberculosis patients.
TAK1 regulates Nrf2 (show GABPA Antibodies) through modulation of Keap-p62/SQSTM1 (show SQSTM1 Antibodies) interaction. This regulation is important for homeostatic antioxidant protection in the intestinal epithelium.
Overexpression of TAK1 was strongly associated with positive lymph node metastasis in pancreatic ductal adenocarcinoma.
dysregulation of the TAK1 complex produces a close phenocopy of Frontometaphyseal Dysplasia caused by FLNA (show FLNA Antibodies) mutations; furthermore, the pathogenesis of some of the filaminopathies caused by FLNA (show FLNA Antibodies) mutations might be mediated by misregulation of signaling coordinated through the TAK1 signaling complex
although TAK1 is located at the crossroad of inflammation, immunity, and cancer, this study reports MAP3K7 mutations in a developmental disorder affecting mainly cartilage, bone, and heart
This study suggests that aberrant activity of TAK1 impairs autophagy and subsequently leads to alterations in the vitality of retinal pigment epithelial cells.
TAK1 may be an important factor involved in the pathogenesis of thyroid cancer, and targeted down-regulation of TAK1 may improve the prognosis of patients with thyroid cancer.
Loss of MAP3K7 are associated with esophageal squamous cell carcinoma.
These data, in addition to the fact that Map3k7 is upregulated in the sinus venous-the source of cells for the SAN-suggest that Map3k7 may be an endogenous regulator of the SAN fate
These results present a novel in vivo function, the negative role of TAK1 (show NR2C2 Antibodies) in marginal zone B-cell development that is likely associated with NF-kappaB2 activation.
Tnfr1 (show TNFRSF1A Antibodies) deletion partially restored thymic and lung macrophages.
TAK1 (show NR2C2 Antibodies) is required for PPARgamma (show PPARG Antibodies) transactivation and promotes PPARgamma (show PPARG Antibodies) transcriptional activity synergistically with TAK1 binding protein 1 (TAB1 (show TAB1 Antibodies)).
inhibition of TAK1 (show NR2C2 Antibodies) triggered two caspase 8 (show CASP8 Antibodies) activation pathways through the induction of RIP1 (show RALBP1 Antibodies)-FADD (show FADD Antibodies)-caspase 8 (show CASP8 Antibodies) complex as well as FLIP cleavage/degradation.
Transforming growth factor-beta activated kinase 1 (TAK1) regulation of sterol-regulatory element-binding proteins (SREBPs) critically contributes to the maintenance of liver homeostasis to prevent steatosis, which is a potentially important mechanism to prevent hepatocellular carcinoma (HCC (show FAM126A Antibodies)) development.
TAK1 (show NR2C2 Antibodies) regulates Nrf2 (show NFE2L2 Antibodies) through modulation of Keap-p62/SQSTM1 (show SQSTM1 Antibodies) interaction. This regulation is important for homeostatic antioxidant protection in the intestinal epithelium.
Mekk1 (show MAP2K1 Antibodies) (encoded by Map3k1 (show MAP3K1 Antibodies)) signaling activates Mapks to regulate Cdkn1b (show CDKN1B Antibodies) (encoding p27(Kip1 (show CDKN1B Antibodies))) expression and p27(Kip1 (show CDKN1B Antibodies))-dependent proliferative expansion in response to antigen.
TRADD (show TRADD Antibodies) knockout blunts pressure overload-induced cardiac hypertrophy through mediating TAK1 (show NR2C2 Antibodies)/p38 MAPK (show MAPK14 Antibodies) but not AKT (show AKT1 Antibodies) phosphorylation
this study demonstrates a pivotal role of TAK1 (show NR2C2 Antibodies) in dendritic cells in controlling trichloroethylene-induced contact hypersensitivity response and suggests that targeting TAK1 (show NR2C2 Antibodies) function in DCs may be a viable approach to preventing and treating TCE-related occupational health hazards
The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2\; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.
mitogen-activated protein kinase kinase kinase 7
, TGF-beta-activated kinase TAK1
, TGF-beta activated kinase 1
, TGF-beta-activated kinase 1
, transforming growth factor-beta-activated kinase 1
, mitogen activated protein kinase kinase kinase 7
, transforming growth factor beta-activated kinase 1