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Human NFKBIA Protein expressed in Escherichia coli (E. coli) - ABIN2004994
Scherer, Brockman, Chen, Maniatis, Ballard: Signal-induced degradation of I kappa B alpha requires site-specific ubiquitination. in Proceedings of the National Academy of Sciences of the United States of America 1995
Show all 5 Pubmed References
Combined computational and biochemical studies indicated that the extent of NF-kappaB (show NFKB1 Proteins)-responsive expression of Nfkbia, which encodes IkappaBalpha, inversely correlated with cross-talk. The Nfkbia promoter showed enhanced responsiveness to NF-kappaB (show NFKB1 Proteins) activation in macrophages compared to that in fibroblasts
An intrinsic constitutively activated feedforward signaling circuit composed of IkappaBalpha/NF-kappaB (show NFKB1 Proteins)(p65 (show NFkBP65 Proteins)), miR (show MLXIP Proteins)-196b-3p, Meis2 (show MEIS2 Proteins), and PPP3CC (show PPP3CC Proteins) is formed during the emergence of castration-resistant prostate cancer.
Mechanistic analysis suggest that USP12 may be required for the activation of NFkappaB pathway as knockdown of USP12 reduced the inhibitory phosphorylation of IkappaBalpha, a well characterized inhibitor of NFkappaB nuclear translocation.
SM22alpha (show TAGLN Proteins) is a phosphorylation-regulated (show PHAX Proteins) suppressor of IKK (show CHUK Proteins)-IkappaBalpha-NF-kappaB (show NFKB1 Proteins) signaling cascades.
We found potential links between the alterations in expression of Tsc22d3 (show TSC22D3 Proteins), Nfkbia and Pdyn (show PDYN Proteins), and different aspects of susceptibility to stress.
Specific and constitutive deletion of the inhibitor of NF-kappaB (show NFKB1 Proteins) (IkappaBalpha) in eosinophils in vivo reduced apoptosis during helminth infection
GRK6 (show GRK6 Proteins) directly phosphorylates Nfkbia at Ser32/Ser36. Knockdown of GRK6 (show GRK6 Proteins) suppresses TNF-alpha (show TNF Proteins)-induced NF-kappaappaB signaling.
Results demonstrate novel roles of TNFRII (show TNFRSF1B Proteins) in the regulation of Abeta (show APP Proteins) production, suggesting a potential therapeutic strategy for Alzheimer's disease by up-regulating TNFRII (show TNFRSF1B Proteins) levels and elevating phosphorylated IkappaBalpha by SUMOylation.
Defective lymphoid organogenesis underlies the immune deficiency caused by a heterozygous S32I mutation in IkappaBalpha.
Dengue virus protease interacts with both NF-kappaB inhibitor alpha (IkappaBalpha) and NF-kappaB (show NFKB1 Proteins) inhibitor beta (IkappaBbeta (show NFKBIB Proteins)), cleaving them in a mouse hemorrhage model.
Data collectively demonstrate the functional importance of IkappaBalpha-mediated stripping of NFkappaB from DNA in the kinetic control of NFkappaB signaling.
These findings indicate that genetic polymorphisms of NFKB1A rs696, pre-miR (show MLXIP Proteins)-146a rs2910164 and pre-miR (show MLXIP Proteins)-499 rs3746444 may represent novel markers of AT susceptibility.
XPO1 (show XPO1 Proteins) inhibitor combination therapy with bortezomib or carfilzomib induces nuclear localization of IkappaBalpha and overcomes acquired proteasome inhibitor resistance in human multiple myeloma.
Molecular docking analysis indicated that transcription factor NF-kappaB (show NFKB1 Proteins) was one of the potential molecular targets modulated by DTTF. Specifically, the drug blocked the TNFalpha (show TNF Proteins)-induced phosphorylation of upstream IkappaBalpha kinase in a time-dependent manner leading to the suppression of NF-kappaB (show NFKB1 Proteins) activation and nuclear translocation
FBXO32 (show FBXO32 Proteins) activates NF-kappaB (show NFKB1 Proteins) through IkappaBalpha degradation in inflammatory and genotoxic stress
The results showed that NFKB1 (show NFKB1 Proteins) and NFKBIA single-nucleotide polymorphisms and gastric cancer are related and that the combined effects of polymorphisms in two genes and the NFKBIA gene monomer increased the risk of gastric cancer, and it was found that in different types of gastric cancer (the cardia and non-cardia cancer), susceptible polymorphism sites and combined effects are different.
Double phosphorylation-induced structural changes in the signal-receiving domain of IkappaBalpha in complex with NF-kappaB (show NFKB1 Proteins) have been described.
Here, the authors report amide hydrogen/deuterium exchange data that reveal long-range allosteric changes in the NFkappaB (show NFKB1 Proteins) (RelA (show NFkBP65 Proteins)-p50 (show CD40 Proteins)) heterodimer induced by DNA or IkappaBalpha binding.
Sam68 (show KHDRBS1 Proteins) is essential for DNA damage-induced NF-kappaB (show NFKB1 Proteins) activation and colon tumorigenesis.
Specifically, BCA2 (show RNF115 Proteins) serves as an E3 SUMO ligase in the SUMOylation of IkappaBalpha, which in turn enhances the sequestration of NF-kappaB (show NFKB1 Proteins) components in the cytoplasm. Since HIV-1 utilizes NF-kappaB (show NFKB1 Proteins) to promote proviral transcription, the BCA2 (show RNF115 Proteins)-mediated inhibition of NF-kappaB (show NFKB1 Proteins) significantly decreases the transcriptional activity of HIV-1.
IkappaB-alpha protein was stabilized by COMMD1 (show COMMD1 Proteins), which attenuated NF-kappaB (show NFKB1 Proteins) signaling during Toll (show TLR4 Proteins)-like receptor ligand and tumor necrosis factor alpha (show TNF Proteins) treatment and enhanced HIV-1 latency in latently HIV-1-infected cells.
NFKBIA has a role as a marker of NF-kappaB (show NFKB1 Proteins)/p65 (show SYT1 Proteins) activation in the early embryo.
NF-kappaB (show NFKB1 Proteins) has a role in increasing PDGF-B (show PDGFB Proteins) transcription
AIP1 (show PDCD6IP Proteins) is a novel transducer in TNF (show TNF Proteins)-induced TRAF2 (show TRAF2 Proteins)-dependent activation of ASK1 (show MAP3K5 Proteins) that mediates a balance between JNK (show MAPK8 Proteins) versus NF-kappaB (show NFKB1 Proteins) signaling
GRK5 overexpression causes nuclear accumulation of IkappaB alpha, leading to the inhibition of NFkappaB transcriptional activity.
This gene encodes a member of the NF-kappa-B inhibitor family, which contain multiple ankrin repeat domains. The encoded protein interacts with REL dimers to inhibit NF-kappa-B/REL complexes which are involved in inflammatory responses. The encoded protein moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1-mediated nuclear export. Mutations in this gene have been found in ectodermal dysplasia anhidrotic with T-cell immunodeficiency autosomal dominant disease.
NF-kappa-B inhibitor alpha
, nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
, nuclear factor of kappa light chain gene enhancer in B-cells inhibitor, alpha
, nuclear factor of kappa light polyp gene enhancer in B-cell 1
, major histocompatibility complex enhancer-binding protein MAD3
, nuclear factor of kappa light chain gene enhancer in B-cells
, I kappa B-alpha
, NF-kappaB inhibitor alpha
, REL-associated protein pp40
, Rel-associated pp40
, IkappaB alpha
, Inhibitor of nuclear factor of kappa light chain gene enhancer in B-cells alpha
, Inhibitor of nuclear factor of kappa light chain gene enhancer in B-cells, alpha