Browse our TNFRSF1A Proteins (TNFRSF1A)

Human Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A) interaction partners

1. This preliminary study shows a significant association between higher sTNFRI and lower scores on the short-term visual memory delayed match to sample test in breast cancer patients receiving chemotherapy

2. In the in vitro model, exposing Caco-2 cells to tumor necrosis factor-alpha (TNF-alpha) led to a significant inhibition in RF uptake, an effect that was abrogated upon knocking down TNF receptor 1 (TNFR1). The inhibition in RF uptake was associated with a significant reduction in the expression of hRFVT-3 and -1 protein and mRNA levels, as well as in the activity of the SLC52A3 and SLC52A1 promoters

3. From these experiments, we gained no evidence for inhibitory effects of high concentrations (20-500 nM) of PGRN on the interaction of TNF with TNFR1 and TNFR2.

4. It can be concluded that the mRNA levels of TNFR1 and TNFR2 were not associated with coronary artery disease risk

5. increased circulating levels of sTNFR1 and BNP were associated with loss of kidney function in Type 2 diabetic Egyptian patients

6. Specificity of human anti-variable heavy (VH ) chain autoantibodies and impact on the design and clinical testing of a VH domain antibody antagonist of tumour necrosis factor-alpha receptor 1.

7. TNF receptor 1 (TNFR1)-induced necroptosis is known to require the formation of a RIPK1-RIPK3-mixed lineage kinase domain-like pseudokinase (MLKL) signaling complex (necrosome) that we find compartmentalizes exclusively to caveolin-1-associated detergent-resistant membrane (DRM) vesicles in HT-29 cells.

8. rs1900693 is not associated with the severity of ankylosing spondylitis and responses to anti-tumour necrosis factor biologics.

9. Staphylococcus aureus protein A enhances osteoclastogenesis via TNFR1 and EGFR signaling

10. In rare cases, periodic fever and inflammatory symptoms in adults can be attributed to mutations in NLRP3, MVK and TNFRSF1A.

11. Using a small amount of peripheral blood, successfully detected possible neuron-derived exosome-related blood biomarkers. This is the first study to suggest that not only SYP and TNFR1 but also IL34 are important blood biomarkers for patients with Manic Depressive Disorder.

12. The soluble TNF-RII/I ratio increased profoundly as macrophage activation syndrome developed and correlated positively with disease activity

13. Serum TNFR1 concentrations are associated with major amputation in patients with type 2 diabetic patients.

14. Here, we reported a new PET tracer for targeting TNFR1.

15. TNFRSF1A is a STAT3 target gene that regulates the NF-kappaB pathway.

16. by restraining TNFR1 at the cell surface via sialylation, ST6Gal-I acts as a functional switch to divert signaling toward survival. These collective findings point to a novel glycosylation-dependent mechanism that regulates the cellular response to TNF and may promote cancer cell survival within TNF-rich tumor microenvironments.

17. Elevated TNFRs levels were associated with the risk of cardiovascular and/or all-cause mortality independent of all relevant covariates in patients undergoing haemodialysis

18. It has been demonstrated that the molecular genetic marker +36G TNFR1 (OR=1,25) is involved in the formation Essential Hypertension in individuals with Metabolic Syndrome.

19. Due to the fact that the mutation was not inherited from the parents, it was likely that R426L was a de novo and novel mutation in the TNFRSF1A gene, which can trigger TRAPS or TRAPS-like symptoms.

20. this study evaluated TNFR1 -609G/T polymorphisms association with RA susceptibility in a sample of Mexican patients. Our results suggest that the TNFR1 -609G/T polymorphisms are not associated with RA susceptibility in a sample of Mexican patients.

Mouse (Murine) Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A) interaction partners

1. we conclude that signal integration by NF-kappaB protects developing natural killer T (NKT) cells from death signals emanating from TNFR1, but not from the NKT TCR or Fas.

2. The results of this study suggest that TNFR1 signaling plays an essential role in pain induction after CCI in males but not in females

3. In conclusion, these data provide evidence for a regulatory role of TNF-alpha in diesel exhaust particles-induced pulmonary inflammation and identify TNFR2 as the most important receptor in mediating these inflammatory effects.

4. Atherosclerotic pathology in each Chlamydia pneumoniae (CPN)-infected knockout (KO)mouse group was reduced significantly compared to WT mice, suggesting that both TNFR1 and TNFR2 promote CPN-induced atherosclerosis.

5. Staphylococcus aureus protein A enhances osteoclastogenesis via TNFR1 and EGFR signaling

6. TNF, via TNFRp55 signaling, modulates articular progesterone and cytokine circadian rhythms in late pregnancy.

7. Recognition memory improved with exercise in WT mice, was impaired in TNFR1(-/-) exercise mice, showed non-significant impairment with exercise in TNF(-/-) mice, and no changes in TNFR2(-/-) mice. In spatial learning there were exercise related improvements in WT mice, non-significant but meaningful impairments evident in TNFR1(-/-) exercise mice, modest improvement in TNF(-/-) exercise mice.

8. Transmembrane TNF, TNFR2 and TNFR1 (indirectly) are critical for preventing inflammation during BCG-induced pleurisy in mice.

9. Our work suggested that TNF-alpha and TNF-R1 are the major contributors of TNF signaling pathway in anesthesia-induced spinal cord neurotoxicity. Targeting TNF-alpha / TNF-R1, not TNF-R2 signaling pathway may be the key component to rescue or prevent anesthesia-induced apoptotic injury in spinal cord neurons.

10. Lack of TNF-alpha signaling through Tnfr1 makes the mice more susceptible to acute infection but does not alter state of latency and reactivation of HSV-1.

11. This study demonstrated that the TNFR1, but not TNFR2, is Required for Both Histaminergic and Non-histaminergic Itch in Mice.

12. p55TNFR shedding has a prominent role in Th1 mediated protection against chronic and latent tuberculosis infection

13. p55TNFR-IKK2-Ripk3 signalling orchestrates arthritogenic and death responses in synovial fibroblasts

14. his study shows that CCR-2/TLR-2 triggered signaling in murine peritoneal macrophages intensifies bacterial (Staphylococcus aureus) killing by reactive oxygen species through TNF-R1

15. Results provide experimental data on the existence of a TNFRp55-mediated anti-inflammatory circuit in dendritic cells which might contribute to the protection against reactive arthritis during the resolution of Yersinia entercolitica infection.

16. TNFR1 contributes to ethanol-induced hypertension and oxidative stress in the vasculature.

17. TNFR2 is important for the proliferative expansion of pathogenic Teff cells

18. NEMO deficiency hampered activation of IKK complex in osteoclast precursors, causing arrest of osteoclastogenesis and apoptosis. Interestingly, inhibiting apoptosis by genetic ablation of TNFr1 significantly increased cell survival, but failed to rescue osteoclastogenesis or reverse osteopetrosis.

19. Data indicate that IL-1RI and TNF-1R contribute to regulation of stress-induced, negatively reinforced drinking perhaps through overlapping signaling events downstream of these receptors, while leaving rewarding properties of alcohol largely unaffected.

20. Myeloid-derived suppressor cells from tumor necrosis factor receptor (TNFR) 2(-/-) mice, but not from TNFR1(-/-) mice, failed to promote B-cell responses.

Pig (Porcine) Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A) interaction partners

1. Results indicated that TNFRSF1A activated the TNF signaling pathway and inhibited the NFkappaB signaling pathway in vitro. These findings provide evidence for an immune-related regulatory function for porcine TNFRSF1A.

2. Retinal ischemia results in increased expression of TNF-alpha and its receptors (TNF-R1 and TNF-R2).

Zebrafish Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A) interaction partners

1. Targeted gene knockdown of TNFRSF1B in zebrafish embryos results in the induction of a caspase-8, caspase-2 and P53-dependent apoptotic program in endothelial cells that bypasses caspase-3.

Cow (Bovine) Tumor Necrosis Factor Receptor Superfamily, Member 1A (TNFRSF1A) interaction partners

1. These results suggest that TNF-alpha sources include immune cells, as well as large and small luteal cells, and that TNF-RI and TNF-RII are present in the luteal cells of the bovine corpus luteum.

2. The expression and cellular localization of tumor necrosis factor-alpha (TNF) and its receptors (TNFRI and TNFRII) mRNAs and proteins, were determined.

3. The upregulation of TNFRI mRNA expression by IFNG suggests that TNF and IFNG synergistically affect the death of luteal endothelial cells resulting in acute luteolysis

4. TNF binding induces release of AIP1 (DAB2IP) from TNFR1, resulting in cytoplasmic translocation and concomitant formation of an intracellular signaling complex comprised of TRADD, RIP1, TRAF2, and AIPl.