TNFSF11 Proteins
79 Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11) Proteins from 15 manufacturers are available on www.antibodies-online.com.
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Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11) (AA 70-244) Protein Protein
Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11) (AA 70 – 244) protein (His tag) Protein
Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11) (AA 63-244) (Active) Protein Protein
Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11) Protein Protein
Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11) (AA 158-317) protein (His-DYKDDDDK-Strep II Tag) Protein
Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11) (AA 157-316), (Soluble) (Active) protein (Fc Tag) Protein
Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11) (AA 1-316) protein (rho-1D4 tag) Protein
Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11) (AA 139-316) protein (rho-1D4 tag) Protein
Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11) (AA 69-317) protein (His tag) Protein
Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11) (AA 70-316) protein (His tag) Protein
TNFSF11 Protein Profile
Protein Summary
This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found.
Alternative names and synonyms associated with TNFSF11
- TNF superfamily member 11 (TNFSF11) antibody
- tumor necrosis factor (ligand) superfamily, member 11 (Tnfsf11) antibody
- TNF superfamily member 11 (Tnfsf11) antibody
- TNF receptor superfamily member 11b (TNFRSF11B) antibody
- TNF superfamily member 11 L homeolog (tnfsf11.L) antibody
- cd254 antibody
- hRANKL2 antibody
- Ly109l antibody
- odf antibody
- OPG antibody
- opgl antibody
- optb2 antibody
- rankl antibody
- sodf antibody
- tnfsf11 antibody
- trance antibody
Protein level used designations for TNFSF11
TNF-related activation-induced cytokine , osteoclast differentiation factor , osteoprotegerin ligand , receptor activator of nuclear factor kappa B ligand , receptor activator of nuclear factor kappa-B ligand , tumor necrosis factor ligand superfamily member 11 , tumor necrosis factor (ligand) superfamily, member 11 , Receptor activator of nuclear factor kappa-B ligand , OPG ligand , receptor activator of NF-kappaB ligand , tumor necrosis factor-related activation-induced cytokine , ODF , OPGL , TRANCE , osteoprotegerin , TNF superfamily member 11 L homeolog , tumor necrosis factor superfamily member 11 L homeolog
GENE ID | SPECIES |
---|---|
8600 | Homo sapiens |
467353 | Pan troglodytes |
513836 | Bos taurus |
609418 | Canis lupus familiaris |
699955 | Macaca mulatta |
100599838 | Nomascus leucogenys |
21943 | Mus musculus |
117516 | Rattus norvegicus |
100348133 | Oryctolagus cuniculus |
496322 | Xenopus laevis |
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