Browse our TNFSF11 Proteins (TNFSF11)

This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found.

• TNF superfamily member 11 (TNFSF11)
• TNF receptor superfamily member 11b (TNFRSF11B)
• tumor necrosis factor (ligand) superfamily, member 11 (Tnfsf11)
• TNF superfamily member 11 (Tnfsf11)
• TNF superfamily member 11 L homeolog (tnfsf11.L)

• cd254 protein
• hRANKL2 protein
• Ly109l protein
• odf protein
• OPG protein
• Show all synonym aliases
• opgl protein
• optb2 protein
• rankl protein
• sodf protein
• tnfsf11 protein
• trance protein

TNF-related activation-induced cytokine , osteoclast differentiation factor , osteoprotegerin ligand , receptor activator of nuclear factor kappa B ligand , receptor activator of nuclear factor kappa-B ligand , tumor necrosis factor ligand superfamily member 11 , tumor necrosis factor (ligand) superfamily, member 11 , Receptor activator of nuclear factor kappa-B ligand , osteoprotegerin , tumor necrosis factor receptor superfamily member 11B , tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) , OPG ligand , receptor activator of NF-kappaB ligand , tumor necrosis factor-related activation-induced cytokine , ODF , OPGL , TRANCE , TNF superfamily member 11 L homeolog , tumor necrosis factor superfamily member 11 L homeolog