TNFSF11 Proteins

Protein Summary

This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found.

Alternative names and synonyms associated with TNFSF11

• TNF superfamily member 11 (TNFSF11) antibody
• tumor necrosis factor (ligand) superfamily, member 11 (Tnfsf11) antibody
• TNF superfamily member 11 (Tnfsf11) antibody
• TNF receptor superfamily member 11b (TNFRSF11B) antibody
• TNF superfamily member 11 L homeolog (tnfsf11.L) antibody

• cd254 antibody
• hRANKL2 antibody
• Ly109l antibody
• odf antibody
• OPG antibody
• Show all synonym aliases
• opgl antibody
• optb2 antibody
• rankl antibody
• sodf antibody
• tnfsf11 antibody
• trance antibody

Protein level used designations for TNFSF11

TNF-related activation-induced cytokine , osteoclast differentiation factor , osteoprotegerin ligand , receptor activator of nuclear factor kappa B ligand , receptor activator of nuclear factor kappa-B ligand , tumor necrosis factor ligand superfamily member 11 , tumor necrosis factor (ligand) superfamily, member 11 , Receptor activator of nuclear factor kappa-B ligand , OPG ligand , receptor activator of NF-kappaB ligand , tumor necrosis factor-related activation-induced cytokine , ODF , OPGL , TRANCE , osteoprotegerin , TNF superfamily member 11 L homeolog , tumor necrosis factor superfamily member 11 L homeolog