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anti-Mouse (Murine) MAML1 Antibodies:
anti-Rat (Rattus) MAML1 Antibodies:
anti-Human MAML1 Antibodies:
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Human Polyclonal MAML1 Primary Antibody for IHC (p), IHC - ABIN250008
Wu, Aster, Blacklow, Lake, Artavanis-Tsakonas, Griffin: MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors. in Nature genetics 2000
BCL6 (show BCL6 Antibodies) inhibits transcription by competing for the Notch1 (show NOTCH1 Antibodies) intracellular domain, preventing the coactivator Mastermind-like1 (MAM1) from binding.
XMam1 has the ability to induce the cell fate into the neurogenic lineage in a Notch (show NOTCH1 Antibodies)-independent manner
Similar phenotypes were observed by conditionally misexpressing a dominant negative form of MAML1 in Mitral cells ( MCs (show SMCP Antibodies))after their migration. Furthermore, the intracellular domain of Notch1 (show NOTCH1 Antibodies) (NICD1) was localized to nuclei of MCs (show SMCP Antibodies). These findings suggest that Notch (show NOTCH1 Antibodies) signaling at embryonic stages is involved in the dendritic complexity of MCs (show SMCP Antibodies)
These observations suggest that chondrocyte maturation was impaired in MAML1(-/-) mice. MAML1 enhances the transcriptional activity of Runx2 (show RUNX2 Antibodies) and plays a role in bone development.
This study demonstrated that targeting Maml1-induced tumor cell senescence and differentiation may alter the tumor microenvironment and cytokine and chemokine (show CCL1 Antibodies) profiles and may also promote innate and adaptive immune cell infiltration and function.
Maml-mediated Notch (show NOTCH1 Antibodies) signaling plays a pivotal role in the initiation and maintenance of goblet cell differentiation for normal ocular surface morphogenesis.
Mastermind-like 1 (MamL1) and mastermind-like 3 (MamL3 (show MAML3 Antibodies)) are essential for Notch (show NOTCH1 Antibodies) signaling in vivo.
Data demonstrate that Mesp2 (show Mesp2 Antibodies) potently represses Notch (show NOTCH1 Antibodies) signaling by inducing the destabilization of mastermind-like 1, a core regulator of this pathway.
MAML1 is a novel modulator for NF-kappaB (show NFKB1 Antibodies) signaling and regulates cellular survival.
There seems to be close correlation of the spatial and temporal expression of Maml1, in the central nervous system (CNS) during early development, implicating a role for the Maml1 gene in neurogenesis.
a dominant negative mutant of MAML1 resulted in early inhibition of T-cell development and the appearance of intrathymic B cells, phenotypes consistent with Notch1 (show NOTCH1 Antibodies) inhibition
MAML1 acts as a coactivator for MEF2C (show MEF2C Antibodies) transcription and is essential for proper muscle development
Authors report that p300 (show EP300 Antibodies) and CBP (show CREBBP Antibodies) acetylate Mastermind-like 1 (Maml1) on amino acid residues K188 and K189 to recruit NACK to the Notch1 (show NOTCH1 Antibodies) ternary complex, which results in the recruitment of RNA polymerase II (show 0 Antibodies) to initiate transcription.
MAML1 may play an important role in tumor progression of Hepatocellular Carcinoma.
Notch (show NOTCH1 Antibodies) signaling was altered in almost half of the clear-cell renal cell carcinoma (show MOK Antibodies) patients and copy number variances in MAML1 and KAT2B (show KAT2B Antibodies) were predominant changes.
The transcriptional coregulator MAML1 affects DNA methylation (show HELLS Antibodies) and gene expression patterns in human embryonic kidney cells.
study identifies that MAML1 is ubiquitinated in the absence of Notch (show NOTCH1 Antibodies) signaling to maintain low levels of MAML1 in the cell
In MCF-7 cells p53 (show TP53 Antibodies) associates with the Notch (show NOTCH1 Antibodies) transcriptional complex (NTC) in a MAML1-dependent fashion, most likely through a p53 (show TP53 Antibodies)-MAML1 interaction.
The impact of MAML1 genetic variants to heart rate was discovered.
Data indicate that EpCAM (show EPCAM Antibodies), CK19 (show KRT19 Antibodies), and hMAM triple-marker-positive circulating tumor cells (CTCs) were detected in 86 of 98 (87.8 %) patients.
Snail (show SNAI1 Antibodies) decreased transcription of Notch1 (show NOTCH1 Antibodies) intracellular domain (NICD (show NOTCH1 Antibodies)) target genes via competing with MAML1, co-activator, in NICD (show NOTCH1 Antibodies) complex.
Authors report that human papillomavirus type 8 E6 subverts NOTCH (show NOTCH1 Antibodies) activation during keratinocyte differentiation by inhibiting RBPJ (show RBPJ Antibodies)/MAML1 transcriptional activator complexes at NOTCH (show NOTCH1 Antibodies) target DNA.
This protein is the human homolog of mastermind, a Drosophila protein that plays a role in the Notch signaling pathway involved in cell-fate determination. There is in vitro evidence that the human homolog forms a complex with the intracellular portion of human Notch receptors and can increase expression of a Notch-induced gene. This evidence supports its proposed function as a transcriptional co-activator in the Notch signaling pathway.
, mastermind-like 1
, mastermind-like protein 1
, mastermind homolog