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The results of the present study show that RNA interference targeting against Notch-4 expression suppresses prostate cancer progression.
Sirt6 (show SIRT6 Proteins) inhibits Notch1 (show NOTCH1 Proteins) and Notch4 transcription by deacetylating histone H3K9.
Very rare missense variant in the regulatory NODP domain of NOTCH4 located at the 6p21 locus was identified in a single family.This family suggests a novel mechanism of systemic sclerosis pathogenesis in which a rare and penetrant coding variation can substantially elevate disease risk in contrast to the more modest non-coding variation typically found at this locus.
High NOTCH4 expression is associated with preeclampsia.
Reduced NOTCH3 (show NOTCH3 Proteins)/NICD3 and NOTCH4/NICD4 in miR (show MLXIP Proteins)-96- and miR (show MLXIP Proteins)-183-expressing nasopharyngeal carcinoma (NPC (show NPC1 Proteins)) cells suggest the involvement of the NOTCH (show NOTCH1 Proteins) signaling pathway in their tumor suppressive function.
Data indicate that mRNA high expression level of Notch1 (show NOTCH1 Proteins) was associated with better overall survival (OS) for all NSCLC, hazard ratio (HR), better OS in adenocarcinoma (Ade), HR, as well as in squamous cell carcinoma (SCC (show CYP11A1 Proteins)), HR, and mRNA high expression levels of Notch2 (show NOTCH2 Proteins) and Notch3 (show NOTCH3 Proteins) were associated with worsen OS for all NSCLC, and mRNA high expression level of Notch4 was not found to be associated with to OS for all NSCLC.
Low levels of Notch pathway genes Notch1, Notch2, Notch4 and Jagged1 correlated with poor prognostic factors such as larger tumor size, positive lymph-node status, tumor phenotype and infiltrating tumor Treg cells.
Data suggest that the vascular DLL4 (show DLL4 Proteins)-Notch4 signaling and VEGF (show VEGFA Proteins) signaling complementing each other plays an important role in the progression of tumor angiogenesis in primary glioblastoma.
findings indicate that Notch4+ melanoma cancer stem-like cells trigger epithelial-mesenchymal transition and promote the metastasis of melanoma cells
the aberrant activation of Notch4 promotes oral squamous cell carcinoma metastasis.
this study shows that Notch (show NOTCH1 Proteins) signaling regulates basophils biological function, at least partially via the modulation of MAPK (show MAPK1 Proteins)
Report impaired Notch4 signaling in endothelial progenitor cells isolated from mouse Kawasaki disease model.
Notch4-knock-out mice that also lacked Notch1 (show NOTCH1 Proteins), had defects in all vascular beds.
Relative to air-exposed controls, ozone increased bronchoalveolar lavage fluid protein, a marker of lung permeability, in all genotypes, but significantly greater concentrations were found in Notch4-/- compared with wild-type and Notch3 (show NOTCH3 Proteins)-/- mice.
Constitutively active Notch4 receptor elicits brain arteriovenous malformations through enlargement of capillary-like vessels.
Notch (show NOTCH1 Proteins) signaling is required for proper lymphatic valve formation and regulates integrin alpha9 and fibronectin (show FN1 Proteins) EIIIA expression during valve morphogenesis
Notch4-deficient mice exhibited slightly delayed vessel growth in the retina, consistent with the novel finding that NOTCH4 protein is expressed in the newly formed vasculature.
Data indicate that expression of Dll4 (show DLL4 Proteins) is specific to theca layer endothelial cells (ECs); Notch1 (show NOTCH1 Proteins)/Notch4 in theca layer ECs and vascular smooth muscle cells (VSMCs), Notch3 (show NOTCH3 Proteins) is restricted to VSMCs; Notch2 (show NOTCH2 Proteins) in granulosa cells (GCs (show UGCG Proteins)) of small follicles.
In this study, we examined Notch (show NOTCH1 Proteins) signaling in the well established Tg26 mouse model of HIV associated nephropathy.
This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. This gene may be associated with susceptibility to schizophrenia in a small portion of cases. An alternative splice variant has been described but its biological nature has not been determined.
Notch homolog 4
, neurogenic locus notch homolog protein 4
, notch 4
, neurogenic locus notch homolog protein 4-like
, Notch gene homolog 4
, putative Notch4 protein