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This study for the first time shows the presence and distribution of CMPK2 in different tissues of zebrafish, but also demonstrates its antiviral potential against SVCV infection in vivo. These new findings could contribute to explain the molecular mechanism of the CMPK2 mediated antiviral function.
Upregulated in monocyte/macrophage differentiating cells, suggesting coordinated regulation with the terminal differentiation program.
a human mitochondrial UMP-CMP kinase (UMP-CMPK, cytidylate kinase; EC 126.96.36.199), designated as UMP-CMP kinase 2 (UMP-CMPK2), is identified.
This gene encodes one of the enzymes in the nucleotide synthesis salvage pathway that may participate in terminal differentiation of monocytic cells. Multiple transcript variants encoding different isoforms have been found for this gene.
cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
, UMP-CMP kinase 2-like
, UMP-CMP kinase 2, mitochondrial
, cytidylate kinase 2
, mitochondrial UMP-CMP kinase
, thymidine monophosphate kinase 2
, thymidylate kinase family LPS-inducible member
, thymidylate kinase LPS-inducible member
, thymidylate kinase homologue