Browse our anti-ATM (ATM) Antibodies

Fruit Fly (Drosophila melanogaster) Ataxia Telangiectasia Mutated (ATM) interaction partners

1. our data indicate that ATR and ATM are both needed for intestinal stem cell maintenance and proliferation; ATR seems to play a bigger role than does ATM.

2. TCTP (show TPT1 Antibodies) has a role in regulating ATM activity to control genome stability and organ development in Drosophila melanogaster

3. A stringent requirement for the conserved function of Ataxia Telangiectasia Mutated (ATM) in telomere protection during early embryonic development, is identified.

4. ATM is primarily required for the meiotic DSB repair response, which includes functions in DNA damage repair and negative feedback control over the level of programmed DSBs during meiosis.

5. Molecular genetic characterization of Drosophila ATM conserved functional domains.

6. ATM checkpoint kinase (show ATR Antibodies) plays a role in telomere maintenance that is independent of telomerase regulation.

7. Drosophila ATM and Mre11 (show MRE11A Antibodies) are essential for the G2/M checkpoint induced by low-dose irradiation.

8. Results suggest that ATM and ATR protect telomere integrity by safeguarding chromatin architecture that favors the loading of telomere-elongating, capping, and silencing proteins.

Xenopus laevis Ataxia Telangiectasia Mutated (ATM) interaction partners

1. Dna2 (show DNA2 Antibodies) co-localizes in foci with RPA (show RPA1 Antibodies) and is found in a complex with replication fork components And-1 and Mcm10 (show MCM10 Antibodies). Dna2 (show DNA2 Antibodies) interacts with the DSB repair and checkpoint proteins Nbs1 (show NLRP2 Antibodies) and ATM.

2. ATM and ATR (show ATR Antibodies) prevent accumulation of chromosomal abnormalities by promoting Mre11 (show MRE11A Antibodies)/Rad50 (show RAD50 Antibodies)/Nbs1 (show NLRP2 Antibodies) dependent recovery of collapsed replication forks.

3. ATM and ATR (show ATR Antibodies) phosphorylate the functionally critical replication protein Mcm2 (show MCM2 Antibodies) during both DNA damage and replication checkpoint responses in Xenopus egg extracts

4. PP2A counteracts ATM and ATR in a DNA damage checkpoint in Xenopus egg extracts

5. Data show that ATM (ataxia-telangiectasia mutated) regulates Xenopus TopBP1 (show TOPBP1 Antibodies) by phosphorylating serine 1131 and thereby strongly enhancing association of TopBP1 (show TOPBP1 Antibodies) with ATR (show ATR Antibodies)(ATM and Rad3-related).

6. ATM and ATR (show ATR Antibodies) control mitotic events in vertebrate cells by targeting CEP63 (show CEP63 Antibodies) and centrosome dependent spindle assembly.

7. These findings suggest that the MRN complex is a crucial mediator in the process whereby ATM promotes the TopBP1 (show TOPBP1 Antibodies)-dependent activation of ATR (show ATR Antibodies)-ATRIP (show ATRIP Antibodies) in response to double-stranded DNA breaks.

8. The Fanconi anemia protein (show FANCF Antibodies) FANCM (show FANCM Antibodies) is controlled by FANCD2 (show FANCD2 Antibodies) and the ATR (show ATR Antibodies)/ATM pathways.

Zebrafish Ataxia Telangiectasia Mutated (ATM) interaction partners

1. molecular cloning of the coding sequence of the catalytic domain of the zebrafish homologue of ATM

2. Characterization of ataxia telangiectasia protein.

Human Ataxia Telangiectasia Mutated (ATM) interaction partners

1. study expands the spectrum of ATM pathogenic variants in Iran.

2. Our data showed that relative TP53 (show TP53 Antibodies) mRNA expression was not significantly altered in both tissues exposed to lasers. For ATM, relative mRNA expression in skin tissue was not significantly altered, but in muscle tissue, laser exposure increased relative ATM mRNA expression. Low-level red and infrared laser radiations alter ATM mRNA expression related to DNA stability in skeletal muscle tissue.

3. The ATM and Rad3-Related (ATR) Protein Kinase (show ATR Antibodies) Pathway Is Activated by Herpes Simplex Virus 1 and Required for Efficient Viral Replication

4. ATM could be activated by lung cancer-associated TNF-alpha (show TNF Antibodies), up-regulate MMP-13 (show MMP13 Antibodies) expression and thereby augment tumor metastasis

5. these results indicate that ATM loss seems to be an early event in non-small cell lung cancer carcinogenesis and is an independent prognostic factor associated with worse survival in stage II/III patients.

6. Low ATM gene expression is associated with breast cancer.

7. Our results demonstrate that sorafenib combined with KU-55933 ( specific ATM inhibitor)treatment does effectively inhibit proliferation of HCC (show FAM126A Antibodies) cell lines synergistically. These data suggests that KU-55933 may be a promising chemosensitizer to sorafenib in the treatment of HCC (show FAM126A Antibodies)

8. Authors further showed that LRRK2 phosphorylation is abolished in the absence of ATM, suggesting that LRRK2 phosphorylation requires ATM.

9. somatic mutations in the ataxia-telangiectasia mutated gene may have an effect of the phenotype of non-small cell lung cancer

10. We found that phosphorylation of histone H2AX on Ser139 (gamma-H2AX (show H2AFX Antibodies)), a biomarker of DSBs, and phosphorylation of ATM at Ser1981, Chk2 (show CHEK2 Antibodies) at Thr68, and p53 (show TP53 Antibodies) at Ser15, part of signaling pathways associated with DSBs, are elevated in these cells.

Pig (Porcine) Ataxia Telangiectasia Mutated (ATM) interaction partners

1. Ataxia telangiectasia (AT) is a progressive multisystem disorder caused by mutations in the AT-mutated (ATM) gene. We engineered a novel porcine model of AT

2. ATM influenced the meiotic and cytoplasmic maturation of porcine oocytes.

3. ATM plays critical role in arsenite induced G2/M phase arrest in aortic endothelial cells possibly via regulation of checkpoint signaling molecules.

Cow (Bovine) Ataxia Telangiectasia Mutated (ATM) interaction partners

1. radiation-induced eNOS (show NOS3 Antibodies) activation in bovine aortic endothelial cells is regulated by ATM and HSP90 (show HSP90 Antibodies)

Mouse (Murine) Ataxia Telangiectasia Mutated (ATM) interaction partners

1. H2AX (show H2AFX Antibodies) shows a similar influence as ATM.

2. The ATM protein is a key mediator of H2O2 preconditioning.

3. ATM is the primary kinase responsible for phosphorylation of Hsp90alpha (show HSP90AA2 Antibodies) after exposure ionizing radiation.

4. These findings define an antagonistic function of ATM and MAPK7 (show MAPK7 Antibodies) in the thymocyte response to DNA damage, and suggest that the lack of MAPK7 (show MAPK7 Antibodies) inhibits thymic lymphoma growth in Atm-/- mice by partially restoring the DNA damage response in thymocytes.

5. ATM/G6PD (show G6PD Antibodies)-driven redox metabolism promotes FLT3 (show FLT3 Antibodies) inhibitor resistance in acute myeloid leukemia (show BCL11A Antibodies) that can be successfully reversed.

6. Baf60b (show SMARCD2 Antibodies), a member of the SWI/SNF chromatin remodeling complex (show SMARCA2 Antibodies), links chromatin opening to ATM activation by facilitating ATM recruitment to the open chromatin regions of a panel of hepatic gene loci.

7. Results demonstrate that alterations in ATM levels are responsible for pronounced and anticipated GABAergic development and function. Since GABA transmission is strongly linked to the correct brain development and plasticity, this study lays basics for both a more clear comprehension of mechanisms associated with brain development.

8. These data indicate that defective Atm reduces the redox homeostasis of the testis and genetic integrity of sperm by regulating glutathione levels independently from G6PDH (show G6PD Antibodies) activity.

9. WSB1 (show WSB1 Antibodies) is one of the key players of early oncogenic events through ATM degradation and destruction of the tumorigenesis barrier.

10. Collectively, these data indicated that ATR (show ATR Antibodies) or ATM inhibition represent potential therapeutic strategies for the treatment of AML (show RUNX1 Antibodies), especially MLL (show MLL Antibodies)-driven leukemias.