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anti-Human ATM Antibodies:
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Human Monoclonal ATM Primary Antibody for ChIP, ELISA - ABIN151775
Naka, Tachibana, Ikeda, Motoyama: Stress-induced premature senescence in hTERT-expressing ataxia telangiectasia fibroblasts. in The Journal of biological chemistry 2004
Show all 114 Pubmed References
Human Polyclonal ATM Primary Antibody for ICC, FACS - ABIN151030
Out, Hoekstra, de Jager, de Vos, van der Westhuyzen, Webb, Van Eck, Biessen, Van Berkel: Adenovirus-mediated hepatic overexpression of scavenger receptor class B type I accelerates chylomicron metabolism in C57BL/6J mice. in Journal of lipid research 2005
Show all 77 Pubmed References
Human Monoclonal ATM Primary Antibody for ICC, IF - ABIN151622
Lai, Chun, Nahas, Mitui, Gamo, Du, Gatti: Correction of ATM gene function by aminoglycoside-induced read-through of premature termination codons. in Proceedings of the National Academy of Sciences of the United States of America 2004
Show all 26 Pubmed References
Human Monoclonal ATM Primary Antibody for ICC, IF - ABIN151772
Yalcin, Zhang, Luciano, Mungamuri, Marinkovic, Vercherat, Sarkar, Grisotto, Taneja, Ghaffari: Foxo3 is essential for the regulation of ataxia telangiectasia mutated and oxidative stress-mediated homeostasis of hematopoietic stem cells. in The Journal of biological chemistry 2008
Show all 20 Pubmed References
Human Polyclonal ATM Primary Antibody for IP, PLA - ABIN151739
Kirshner, Jobling, Pajares, Ravani, Glick, Lavin, Koslov, Shiloh, Barcellos-Hoff: Inhibition of transforming growth factor-beta1 signaling attenuates ataxia telangiectasia mutated activity in response to genotoxic stress. in Cancer research 2006
Show all 4 Pubmed References
Human Polyclonal ATM Primary Antibody for IHC - ABIN362100
Kang, Guo, Tan, Zhao, Tang, Lu: Expression status of ataxia-telangiectasia-mutated gene correlated with prognosis in advanced gastric cancer. in Mutation research 2008
Show all 8 Pubmed References
Human Monoclonal ATM Primary Antibody for ELISA, WB - ABIN965618
ORegan, Kiely, OGara: Expression of the adenyl cyclase-encoding gene (cya) of Rhizobium meliloti F34: existence of two cya genes? in Gene 1990
Show all 4 Pubmed References
Human Monoclonal ATM Primary Antibody for ICC, IF - ABIN2668604
Shrivastav, Miller, De Haro, Durant, Chen, Chen, Nickoloff: DNA-PKcs and ATM co-regulate DNA double-strand break repair. in DNA repair 2009
Show all 3 Pubmed References
Human ATM Primary Antibody for IHC - ABIN965619
Gupta, Sharma, Young, Agarwal, Smith, Paull, Lucchesi, Khanna, Ludwig, Pandita: Involvement of human MOF in ATM function. in Molecular and cellular biology 2005
Show all 4 Pubmed References
Human Polyclonal ATM Primary Antibody for IF (p), IHC (p) - ABIN679103
Yin, Jiang, Peng, Cui, Zhou, He, Zuo, Ouyang, Fan, Fang: The molecular mechanism of G2M cell cycle arrest induced by AFB1 in the jejunum. in Oncotarget 2016
Show all 2 Pubmed References
our data indicate that ATR and ATM are both needed for intestinal stem cell maintenance and proliferation; ATR seems to play a bigger role than does ATM.
TCTP (show TPT1 Antibodies) has a role in regulating ATM activity to control genome stability and organ development in Drosophila melanogaster
A stringent requirement for the conserved function of Ataxia Telangiectasia Mutated (ATM) in telomere protection during early embryonic development, is identified.
ATM is primarily required for the meiotic DSB repair response, which includes functions in DNA damage repair and negative feedback control over the level of programmed DSBs during meiosis.
Molecular genetic characterization of Drosophila ATM conserved functional domains.
ATM checkpoint kinase (show ATR Antibodies) plays a role in telomere maintenance that is independent of telomerase regulation.
Drosophila ATM and Mre11 (show MRE11A Antibodies) are essential for the G2/M checkpoint induced by low-dose irradiation.
Results suggest that ATM and ATR protect telomere integrity by safeguarding chromatin architecture that favors the loading of telomere-elongating, capping, and silencing proteins.
Dna2 (show DNA2 Antibodies) co-localizes in foci with RPA (show RPA1 Antibodies) and is found in a complex with replication fork components And-1 and Mcm10 (show MCM10 Antibodies). Dna2 (show DNA2 Antibodies) interacts with the DSB repair and checkpoint proteins Nbs1 (show NLRP2 Antibodies) and ATM.
ATM and ATR (show ATR Antibodies) prevent accumulation of chromosomal abnormalities by promoting Mre11 (show MRE11A Antibodies)/Rad50 (show RAD50 Antibodies)/Nbs1 (show NLRP2 Antibodies) dependent recovery of collapsed replication forks.
ATM and ATR (show ATR Antibodies) phosphorylate the functionally critical replication protein Mcm2 (show MCM2 Antibodies) during both DNA damage and replication checkpoint responses in Xenopus egg extracts
PP2A counteracts ATM and ATR in a DNA damage checkpoint in Xenopus egg extracts
Data show that ATM (ataxia-telangiectasia mutated) regulates Xenopus TopBP1 (show TOPBP1 Antibodies) by phosphorylating serine 1131 and thereby strongly enhancing association of TopBP1 (show TOPBP1 Antibodies) with ATR (show ATR Antibodies)(ATM and Rad3-related).
ATM and ATR (show ATR Antibodies) control mitotic events in vertebrate cells by targeting CEP63 (show CEP63 Antibodies) and centrosome dependent spindle assembly.
These findings suggest that the MRN complex is a crucial mediator in the process whereby ATM promotes the TopBP1 (show TOPBP1 Antibodies)-dependent activation of ATR (show ATR Antibodies)-ATRIP (show ATRIP Antibodies) in response to double-stranded DNA breaks.
The Fanconi anemia protein (show FANCF Antibodies) FANCM (show FANCM Antibodies) is controlled by FANCD2 (show FANCD2 Antibodies) and the ATR (show ATR Antibodies)/ATM pathways.
molecular cloning of the coding sequence of the catalytic domain of the zebrafish homologue of ATM
Characterization of ataxia telangiectasia protein.
ATM was downregulated in gastric cancer patients in Xinjiang, especially for Uygurs and Kazaks, which suggested ATM to be an independent indicator of prognosis for GC therapy.
The mRNA levels of ATR (show ANTXR1 Antibodies) and ATM and the expression of ATR (show ANTXR1 Antibodies) and ATM protein in NPC (show NPC1 Antibodies) tissues were significantly higher than those in adjacent normal tissues. The colony formation assay showed that the colony-forming rate decreased, showing radiation dose-dependent and CGK (show PRKG1 Antibodies)-733 concentration-dependent manners.
study expands the spectrum of ATM pathogenic variants in Iran.
Our data showed that relative TP53 (show TP53 Antibodies) mRNA expression was not significantly altered in both tissues exposed to lasers. For ATM, relative mRNA expression in skin tissue was not significantly altered, but in muscle tissue, laser exposure increased relative ATM mRNA expression. Low-level red and infrared laser radiations alter ATM mRNA expression related to DNA stability in skeletal muscle tissue.
The ATM and Rad3-Related (ATR) Protein Kinase (show ATR Antibodies) Pathway Is Activated by Herpes Simplex Virus 1 and Required for Efficient Viral Replication
ATM could be activated by lung cancer-associated TNF-alpha (show TNF Antibodies), up-regulate MMP-13 (show MMP13 Antibodies) expression and thereby augment tumor metastasis
these results indicate that ATM loss seems to be an early event in non-small cell lung cancer carcinogenesis and is an independent prognostic factor associated with worse survival in stage II/III patients.
Low ATM gene expression is associated with breast cancer.
Our results demonstrate that sorafenib combined with KU-55933 ( specific ATM inhibitor)treatment does effectively inhibit proliferation of HCC (show FAM126A Antibodies) cell lines synergistically. These data suggests that KU-55933 may be a promising chemosensitizer to sorafenib in the treatment of HCC (show FAM126A Antibodies)
Authors further showed that LRRK2 phosphorylation is abolished in the absence of ATM, suggesting that LRRK2 phosphorylation requires ATM.
Ataxia telangiectasia (AT) is a progressive multisystem disorder caused by mutations in the AT-mutated (ATM) gene. We engineered a novel porcine model of AT
ATM influenced the meiotic and cytoplasmic maturation of porcine oocytes.
ATM plays critical role in arsenite induced G2/M phase arrest in aortic endothelial cells possibly via regulation of checkpoint signaling molecules.
radiation-induced eNOS (show NOS3 Antibodies) activation in bovine aortic endothelial cells is regulated by ATM and HSP90 (show HSP90 Antibodies)
ATM haplodeficiency decreases fibroblast senescence and vascular endothelial growth factor (show VEGF Antibodies) production and impaired angiogenesis in response to myocardial infarction, leading to accelerated heart failure.
H2AX (show H2AFX Antibodies) shows a similar influence as ATM.
The ATM protein is a key mediator of H2O2 preconditioning.
ATM is the primary kinase responsible for phosphorylation of Hsp90alpha (show HSP90AA2 Antibodies) after exposure ionizing radiation.
These findings define an antagonistic function of ATM and MAPK7 (show MAPK7 Antibodies) in the thymocyte response to DNA damage, and suggest that the lack of MAPK7 (show MAPK7 Antibodies) inhibits thymic lymphoma growth in Atm-/- mice by partially restoring the DNA damage response in thymocytes.
ATM/G6PD (show G6PD Antibodies)-driven redox metabolism promotes FLT3 (show FLT3 Antibodies) inhibitor resistance in acute myeloid leukemia (show BCL11A Antibodies) that can be successfully reversed.
Baf60b (show SMARCD2 Antibodies), a member of the SWI/SNF chromatin remodeling complex (show SMARCA2 Antibodies), links chromatin opening to ATM activation by facilitating ATM recruitment to the open chromatin regions of a panel of hepatic gene loci.
Results demonstrate that alterations in ATM levels are responsible for pronounced and anticipated GABAergic development and function. Since GABA transmission is strongly linked to the correct brain development and plasticity, this study lays basics for both a more clear comprehension of mechanisms associated with brain development.
These data indicate that defective Atm reduces the redox homeostasis of the testis and genetic integrity of sperm by regulating glutathione levels independently from G6PDH (show G6PD Antibodies) activity.
WSB1 (show WSB1 Antibodies) is one of the key players of early oncogenic events through ATM degradation and destruction of the tumorigenesis barrier.
The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates\; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder.
, ataxia telangiectasia mutated
, ataxia telengiesctasia mutated
, ataxia-telangiectasia mutated
, drosophila ATM
, ataxia telangiectasia mutated (includes complementation groups A, C and D)
, ataxia telangiectasia mutated protein
, serine-protein kinase ATM-like
, ataxia telangiectasia mutated (atm)
, A-T mutated
, AT mutated
, TEL1, telomere maintenance 1, homolog
, serine-protein kinase ATM
, Ataxia telangiectasia gene mutated in human beings
, ataxia telangiectasia mutated homolog
, A-T mutated homolog
, ATM (ataxia telangiectasia mutated)
, ataxia telangiectasia gene mutated in human beings