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ATDC is required for TP63-induced bladder tumor invasion and metastasis.
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a case of a 4-month-old infant homozygous for the 2 ATM mutations, who developed malignant peritoneal mesothelioma and died by the age of 2 years.
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the mitochondrial functional recovery by ATM inhibition might represent a promising strategy to ameliorate the accelerated aging phenotypes and to treat age-related disease.
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The regulation of ATM in autophagy is including mitophagy, pexophagy, and lipophagy, which would enhance our understanding of its role in cell dynamics and homeostasis.
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Here, the authors show that ARP8, a subunit of the INO80 chromatin remodeling complex, is phosphorylated after etoposide treatment. The etoposide-induced phosphorylation of ARP8 is regulated by ATM and ATR, and attenuates its interaction with INO80.
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SIM2s interacts with ATM and is stabilized through ATM-dependent phosphorylation in response to IR.
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In each of these domains, key molecules and pathways have now been identified, including the glycolytic enzymes PFKFB3 and G6PD; the DNA repair molecules ATM, DNA-PKcs and MRE11A; and the podosome marker protein TKS5. Some of these molecules may help in defining targetable pathways to slow the T cell aging process. [review]
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Rare germline variants in ATM are associated with chronic lymphocytic leukemia.
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Which was induced by phosphorylation and ATM gene expression.
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Study findings reveal that ufmylation of histone H4 by UFL1 is an important step for amplification of ATM activation and maintenance of genomic integrity.
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associations between CD40L/IL-4 response and baseline ATM levels, induction of ATM, and phosphorylation of the ATM targets, p53 and H2AX. X-irradiation was used to demonstrate that CD40L/IL-4 stimulation tended to improve DNA damage repair.
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This non-canonical activation of STING is mediated by the DNA binding protein IFI16, together with the DNA damage response factors ATM and PARP-1.
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ATM activation at mammalian telomeres with reduced TRF2 or at human telomeres during mitotic arrest occurs specifically with a structural change from telomere loops (t-loops) to linearized telomeres.
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Although ATM is involved in the DNA damage response, ATM-associated tumours are distinct from BRCA1-associated tumours in terms of morphological characteristics and genomic alterations, and they are also distinguishable from sporadic breast tumours, thus opening up the possibility to identify ATM variant carriers outside the ataxia-telangiectasia disorder and direct them towards effective cancer risk management and therap
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Invasive breast carcinomas with variants of uncertain significance in the ATM gene showed similar histopathologic features.
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ATM SNP rs11212617 significantly affected the effect of metformin and metformin plasma concentration.
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The ATR-Chk1 and ATM-Chk2 signalings in male breast cancer (MBC).
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Localization of active phosphorylated Ataxia Telangiectasia Mutated Protein (pATM) to adenovirus control protein E4 deletion mutants (E4-) viral replication centers (VRCs) is important for its inhibitory effect in viral DNA replication. ATM is necessary for localization of RNF8 and 53BP1 to E4- VRCs, but recruitment of DDR factors Mre11, Mdc1 and gammaH2AX is ATM-independent, indicating that ATM affect viral chromatin ...
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study outlined the immunohistochemical expression of p-ATM/p53 in glioblastomas and provided data on their possible prognostic/predictive of response role. A "non-oncogene addiction" to ATM for NEp53 glioblastoma could be postulated, strengthening the rationale for development of ATM inhibiting drugs.
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Deficient activation of ATM by the Mre11-Rad50-Nbs1 complex and DNA double-strand breaks resulted in loss of cell viability, checkpoint activation, and DNA end resection in response to DNA damage.
