Browse our anti-ATM (ATM) Antibodies

Fruit Fly (Drosophila melanogaster) Ataxia Telangiectasia Mutated (ATM) interaction partners

1. our data indicate that ATR and ATM are both needed for intestinal stem cell maintenance and proliferation; ATR seems to play a bigger role than does ATM.

2. TCTP (show TPT1 Antibodies) has a role in regulating ATM activity to control genome stability and organ development in Drosophila melanogaster

3. A stringent requirement for the conserved function of Ataxia Telangiectasia Mutated (ATM) in telomere protection during early embryonic development, is identified.

4. ATM is primarily required for the meiotic DSB repair response, which includes functions in DNA damage repair and negative feedback control over the level of programmed DSBs during meiosis.

5. Molecular genetic characterization of Drosophila ATM conserved functional domains.

6. ATM checkpoint kinase (show ATR Antibodies) plays a role in telomere maintenance that is independent of telomerase regulation.

7. Drosophila ATM and Mre11 (show MRE11A Antibodies) are essential for the G2/M checkpoint induced by low-dose irradiation.

8. Results suggest that ATM and ATR protect telomere integrity by safeguarding chromatin architecture that favors the loading of telomere-elongating, capping, and silencing proteins.

Xenopus laevis Ataxia Telangiectasia Mutated (ATM) interaction partners

1. Dna2 (show DNA2 Antibodies) co-localizes in foci with RPA (show RPA1 Antibodies) and is found in a complex with replication fork components And-1 and Mcm10 (show MCM10 Antibodies). Dna2 (show DNA2 Antibodies) interacts with the DSB repair and checkpoint proteins Nbs1 (show NLRP2 Antibodies) and ATM.

2. ATM and ATR (show ATR Antibodies) prevent accumulation of chromosomal abnormalities by promoting Mre11 (show MRE11A Antibodies)/Rad50 (show RAD50 Antibodies)/Nbs1 (show NLRP2 Antibodies) dependent recovery of collapsed replication forks.

3. ATM and ATR (show ATR Antibodies) phosphorylate the functionally critical replication protein Mcm2 (show MCM2 Antibodies) during both DNA damage and replication checkpoint responses in Xenopus egg extracts

4. PP2A counteracts ATM and ATR in a DNA damage checkpoint in Xenopus egg extracts

5. Data show that ATM (ataxia-telangiectasia mutated) regulates Xenopus TopBP1 (show TOPBP1 Antibodies) by phosphorylating serine 1131 and thereby strongly enhancing association of TopBP1 (show TOPBP1 Antibodies) with ATR (show ATR Antibodies)(ATM and Rad3-related).

6. ATM and ATR (show ATR Antibodies) control mitotic events in vertebrate cells by targeting CEP63 (show CEP63 Antibodies) and centrosome dependent spindle assembly.

7. These findings suggest that the MRN complex is a crucial mediator in the process whereby ATM promotes the TopBP1 (show TOPBP1 Antibodies)-dependent activation of ATR (show ATR Antibodies)-ATRIP (show ATRIP Antibodies) in response to double-stranded DNA breaks.

8. The Fanconi anemia protein (show FANCF Antibodies) FANCM (show FANCM Antibodies) is controlled by FANCD2 (show FANCD2 Antibodies) and the ATR (show ATR Antibodies)/ATM pathways.

Zebrafish Ataxia Telangiectasia Mutated (ATM) interaction partners

1. molecular cloning of the coding sequence of the catalytic domain of the zebrafish homologue of ATM

2. Characterization of ataxia telangiectasia protein.

Human Ataxia Telangiectasia Mutated (ATM) interaction partners

1. The ATM rs189037, rs664677 and rs664143 gene polymorphisms are risk factors for lung cancer, while the ATM rs189037 variant was significantly associated with radiation-induced pneumonitis risk. [meta-analysis]

2. Moreover, under positive p53 expression, low expression of ATM was highly predictive of poor survival in ACC (p=0.017). CONCLUSION: These data indicate that combined assessment of ATM and p53 expression can serve as a useful prognostic marker for assessing survival rate in patients with ACC [Adenoid cystic carcinoma] of the salivary glands.

3. results reveal how alterations in FBXO31 (show FBXO5 Antibodies) phosphorylation, mediated by AKT (show AKT1 Antibodies) and ATM, underlie physiological regulation of FBXO31 (show FBXO5 Antibodies) levels in unstressed and genotoxically stressed cells

4. Combination of T-cell lymphoma-1 (show TCL1A Antibodies) protein (TCL1 (show TCL1A Antibodies))-overexpression and damaging ataxia telangiectasia mutated protein (ATM) functionally synergistically contribute to T-cell prolymphocytic leukemia (T-PLL) specific phenotype of impaired DNA damage processing.

5. These findings suggested that the ATM/p21 (show CDKN1A Antibodies) pathway directly participated in the LDIR-induced cell proliferation inhibition in p53null type prostate tumor cells, whereas this mechanism was absent in normal prostate cells. Thus, p53 (show TP53 Antibodies) may affect cell stability following LDIR, and plays a crucial role in regulating the ATM/p21 (show CDKN1A Antibodies) pathway activated by LDIR.

6. Truncating variants in PALB2, ATM and CHEK2 , but not XRCC2 were associated with increased breast cancer risk.

7. our results identify a novel link between XRRA1 (show XRRA1 Antibodies) and the ATM/CHK1 (show CHEK1 Antibodies)/2 pathway and suggest that XRRA1 (show XRRA1 Antibodies) is involved in a DNA damage response that drives radio- and chemoresistance by regulating the ATM/CHK1 (show CHEK1 Antibodies)/2 pathway.

8. A target-enrichment next-generation sequencing strategy on 28 Spanish ataxia-telangiectasia patients identified gene variants affecting function in 54 of the 56 alleles analyzed. 28 ATM gene mutations were found, of which 10 have not been reported. A total of 171 gene variants not affecting function were also found; 22 predispose to disease. All Roma patients were homozygous for the same mutation and share haplotype H3.

9. Variations in the ATM gene and its encoding product, the ATM protein, are found to affect the pathogenesis, development, response to treatment and prognosis of lung cancer

10. The polymorphisms rs664143 and rs664677 of ATM are associated with lung cancer occurrence

Pig (Porcine) Ataxia Telangiectasia Mutated (ATM) interaction partners

1. Ataxia telangiectasia (AT) is a progressive multisystem disorder caused by mutations in the AT-mutated (ATM) gene. We engineered a novel porcine model of AT

2. ATM influenced the meiotic and cytoplasmic maturation of porcine oocytes.

3. ATM plays critical role in arsenite induced G2/M phase arrest in aortic endothelial cells possibly via regulation of checkpoint signaling molecules.

Cow (Bovine) Ataxia Telangiectasia Mutated (ATM) interaction partners

1. radiation-induced eNOS (show NOS3 Antibodies) activation in bovine aortic endothelial cells is regulated by ATM and HSP90 (show HSP90 Antibodies)

Mouse (Murine) Ataxia Telangiectasia Mutated (ATM) interaction partners

1. SOD2 (show SOD2 Antibodies) expression is ATM- and RelA (show NFkBP65 Antibodies)-dependent, ATM knockdown renders cells sensitive to pro-oxidant exposure, and SOD mimetics partially rescue this sensitivity. Mice with germline deletion of Atm fail to develop mature mammary glands, but using a conditional knockout approach, we determined that Atm deletion significantly diminished the expression of Sod2 (show SOD2 Antibodies).

2. These data suggest that ATM and ATR are part of the cellular "infrastructure" that maintains the excitatory/inhibitory balance of the nervous system.

3. ATM has a role in homology-directed repair (HDR (show GATA3 Antibodies)) independent of the BRCA1 (show BRCA1 Antibodies)-53BP1 (show TP53BP1 Antibodies) antagonism; its HDR (show GATA3 Antibodies) function can become critical in certain contexts

4. intestinal tuft cells play an important role in regulating the ATM mediated DNA damage response, for epithelial cell survival/self-renewal via a Dclk1 (show DCLK1 Antibodies) dependent mechanism

5. in the Atm(-/-) MEFs, the same Radiofrequency electromagnetic fields exposure for 12 h induced both SSBs and double-strand breaks and activated the two repair processes, which also reduced the DNA damage to less than the control level after prolonged exposure. The observed phenomenon is similar to the hormesis of a toxic substance at a low dose

6. ATM haplodeficiency decreases fibroblast senescence and vascular endothelial growth factor (show VEGF Antibodies) production and impaired angiogenesis in response to myocardial infarction, leading to accelerated heart failure.

7. H2AX (show H2AFX Antibodies) shows a similar influence as ATM.

8. The ATM protein is a key mediator of H2O2 preconditioning.

9. ATM is the primary kinase responsible for phosphorylation of Hsp90alpha (show HSP90AA2 Antibodies) after exposure ionizing radiation.

10. These findings define an antagonistic function of ATM and MAPK7 (show MAPK7 Antibodies) in the thymocyte response to DNA damage, and suggest that the lack of MAPK7 (show MAPK7 Antibodies) inhibits thymic lymphoma growth in Atm-/- mice by partially restoring the DNA damage response in thymocytes.