Browse our anti-ATM (ATM) Antibodies

Fruit Fly (Drosophila melanogaster) Ataxia Telangiectasia Mutated (ATM) interaction partners

1. our data indicate that ATR and ATM are both needed for intestinal stem cell maintenance and proliferation; ATR seems to play a bigger role than does ATM.

2. TCTP (show TPT1 Antibodies) has a role in regulating ATM activity to control genome stability and organ development in Drosophila melanogaster

3. A stringent requirement for the conserved function of Ataxia Telangiectasia Mutated (ATM) in telomere protection during early embryonic development, is identified.

4. ATM is primarily required for the meiotic DSB repair response, which includes functions in DNA damage repair and negative feedback control over the level of programmed DSBs during meiosis.

5. Molecular genetic characterization of Drosophila ATM conserved functional domains.

6. ATM checkpoint kinase (show ATR Antibodies) plays a role in telomere maintenance that is independent of telomerase regulation.

7. Drosophila ATM and Mre11 (show MRE11A Antibodies) are essential for the G2/M checkpoint induced by low-dose irradiation.

8. Results suggest that ATM and ATR protect telomere integrity by safeguarding chromatin architecture that favors the loading of telomere-elongating, capping, and silencing proteins.

Xenopus laevis Ataxia Telangiectasia Mutated (ATM) interaction partners

1. Dna2 (show DNA2 Antibodies) co-localizes in foci with RPA (show RPA1 Antibodies) and is found in a complex with replication fork components And-1 and Mcm10 (show MCM10 Antibodies). Dna2 (show DNA2 Antibodies) interacts with the DSB repair and checkpoint proteins Nbs1 (show NLRP2 Antibodies) and ATM.

2. ATM and ATR (show ATR Antibodies) prevent accumulation of chromosomal abnormalities by promoting Mre11 (show MRE11A Antibodies)/Rad50 (show RAD50 Antibodies)/Nbs1 (show NLRP2 Antibodies) dependent recovery of collapsed replication forks.

3. ATM and ATR (show ATR Antibodies) phosphorylate the functionally critical replication protein Mcm2 (show MCM2 Antibodies) during both DNA damage and replication checkpoint responses in Xenopus egg extracts

4. PP2A counteracts ATM and ATR in a DNA damage checkpoint in Xenopus egg extracts

5. Data show that ATM (ataxia-telangiectasia mutated) regulates Xenopus TopBP1 (show TOPBP1 Antibodies) by phosphorylating serine 1131 and thereby strongly enhancing association of TopBP1 (show TOPBP1 Antibodies) with ATR (show ATR Antibodies)(ATM and Rad3-related).

6. ATM and ATR (show ATR Antibodies) control mitotic events in vertebrate cells by targeting CEP63 (show CEP63 Antibodies) and centrosome dependent spindle assembly.

7. These findings suggest that the MRN complex is a crucial mediator in the process whereby ATM promotes the TopBP1 (show TOPBP1 Antibodies)-dependent activation of ATR (show ATR Antibodies)-ATRIP (show ATRIP Antibodies) in response to double-stranded DNA breaks.

8. The Fanconi anemia protein (show FANCF Antibodies) FANCM (show FANCM Antibodies) is controlled by FANCD2 (show FANCD2 Antibodies) and the ATR (show ATR Antibodies)/ATM pathways.

Zebrafish Ataxia Telangiectasia Mutated (ATM) interaction partners

1. molecular cloning of the coding sequence of the catalytic domain of the zebrafish homologue of ATM

2. Characterization of ataxia telangiectasia protein.

Human Ataxia Telangiectasia Mutated (ATM) interaction partners

1. High ATM expression is associated with chemotherapeutic resistance in gastric cancer.

2. No significant association of ATM rs11212592 with lung cancer was found in five genetic models in Chinese population. Haplotypes consisting of PPP1R13L (show PPP1R13L Antibodies) rs1970764 and ATM rs11212592 may be associated with lung cancer.

3. The miR (show MLXIP Antibodies)-449a/ATDC (show TRIM29 Antibodies) axis plays an important role in the development and progression of pancreatic cancer.

4. The ATM structure shows the detailed topology of the regulator-interacting N-terminal helical solenoid. The ATM conformational dynamics shown by the structures represent an important step in understanding the enzyme regulation.

5. ATM and CDK2 control the chromatin remodeling activity of CSB in the regulation of double strand break repair pathway choice.

6. Data suggest that ataxia telangiectasia mutated protein (ATM) mutational status in lung cancer is a mechanistic biomarker for MEK (show MAP2K1 Antibodies) inhibitor response.

7. Data suggest a close association between the nonfunctionality of ATM/p53 (show TP53 Antibodies) pathway and accumulation of p27Kip1 (show CDKN1B Antibodies) in chronic lymphocytic leukemia (CLL) cells in response to DNA damage.

8. Letter: BRCA2 (show BRCA2 Antibodies)- and ATM-mutated prostate cancer sensitive to high dose testosterone.

9. Radiation-activated ataxia-telangiectasia mutated kinase/p38 (show CRK Antibodies) signaling positively contributed to the nucleus to cytosol translocation of HuR (show ELAVL1 Antibodies).

10. No significant differences were presented in DNA methylation (show HELLS Antibodies) levels of RASSF1A (show RASSF1 Antibodies) and ATM between the sporadic breast cancer cases and the healthy controls.

Pig (Porcine) Ataxia Telangiectasia Mutated (ATM) interaction partners

1. Ataxia telangiectasia (AT) is a progressive multisystem disorder caused by mutations in the AT-mutated (ATM) gene. We engineered a novel porcine model of AT

2. ATM influenced the meiotic and cytoplasmic maturation of porcine oocytes.

3. ATM plays critical role in arsenite induced G2/M phase arrest in aortic endothelial cells possibly via regulation of checkpoint signaling molecules.

Cow (Bovine) Ataxia Telangiectasia Mutated (ATM) interaction partners

1. radiation-induced eNOS (show NOS3 Antibodies) activation in bovine aortic endothelial cells is regulated by ATM and HSP90 (show HSP90 Antibodies)

Mouse (Murine) Ataxia Telangiectasia Mutated (ATM) interaction partners

1. SOD2 (show SOD2 Antibodies) expression is ATM- and RelA (show NFkBP65 Antibodies)-dependent, ATM knockdown renders cells sensitive to pro-oxidant exposure, and SOD mimetics partially rescue this sensitivity. Mice with germline deletion of Atm fail to develop mature mammary glands, but using a conditional knockout approach, we determined that Atm deletion significantly diminished the expression of Sod2 (show SOD2 Antibodies).

2. These data suggest that ATM and ATR are part of the cellular "infrastructure" that maintains the excitatory/inhibitory balance of the nervous system.

3. ATM has a role in homology-directed repair (HDR (show GATA3 Antibodies)) independent of the BRCA1 (show BRCA1 Antibodies)-53BP1 (show TP53BP1 Antibodies) antagonism; its HDR (show GATA3 Antibodies) function can become critical in certain contexts

4. intestinal tuft cells play an important role in regulating the ATM mediated DNA damage response, for epithelial cell survival/self-renewal via a Dclk1 (show DCLK1 Antibodies) dependent mechanism

5. in the Atm(-/-) MEFs, the same Radiofrequency electromagnetic fields exposure for 12 h induced both SSBs and double-strand breaks and activated the two repair processes, which also reduced the DNA damage to less than the control level after prolonged exposure. The observed phenomenon is similar to the hormesis of a toxic substance at a low dose

6. ATM haplodeficiency decreases fibroblast senescence and vascular endothelial growth factor (show VEGF Antibodies) production and impaired angiogenesis in response to myocardial infarction, leading to accelerated heart failure.

7. H2AX (show H2AFX Antibodies) shows a similar influence as ATM.

8. The ATM protein is a key mediator of H2O2 preconditioning.

9. ATM is the primary kinase responsible for phosphorylation of Hsp90alpha (show HSP90AA2 Antibodies) after exposure ionizing radiation.

10. These findings define an antagonistic function of ATM and MAPK7 (show MAPK7 Antibodies) in the thymocyte response to DNA damage, and suggest that the lack of MAPK7 (show MAPK7 Antibodies) inhibits thymic lymphoma growth in Atm-/- mice by partially restoring the DNA damage response in thymocytes.