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Human CDKN1A Protein expressed in HEK-293 Cells - ABIN2713874
Porter, Farmaki, Altilia, Schools, West, Chen, Chang, Puzyrev, Lim, Rokow-Kittell, Friedhoff, Papavassiliou, Kalurupalle, Hurteau, Shi, Baran, Gyorffy, Wentland, Broude, Kiaris, Roninson: Cyclin-dependent kinase 8 mediates chemotherapy-induced tumor-promoting paracrine activities. in Proceedings of the National Academy of Sciences of the United States of America 2012
We characterized the effect of the novel loci through pathway analysis and found that pathways involved are not entirely distinct as assumed so far. Further, we identified a novel association between CDKN1A and POAG. Using a zebrafish model we show that six6b (associated with POAG and optic nerve head variation) alters the expression of cdkn1a
intestinal clock controls the expression of key cell cycle regulators, such as cdc2 (show CDK1 Proteins), wee1 (show WEE1 Proteins), p21, PCNA (show PCNA Proteins) and cdk2 (show CDK2 Proteins), but only weakly influences cyclin B1 (show CCNB1 Proteins), cyclin B2 (show CCNB2 Proteins) and cyclin E1 (show CCNE1 Proteins) expression.
Data show that cortactin (show CTTN Proteins)-mediated p21Cip1 nuclear export and degradation facilitating MCP1 (show CCL2 Proteins)-induced human aortic smooth muscle cell (HASMC) proliferation.
Low P21 expression is associated with clear cell and endometrioid carcinoma of the ovary and the endometrium.
PAK4 (show PAK4 Proteins) downregulated the level of p21 and enhanced the activity of Akt (show AKT1 Proteins) as well. And we conclude that PAK4 (show PAK4 Proteins) acts as a regulator of cell cycle (show C13orf15 Proteins) progression of vascular smooth muscle cells by mediating Akt (show AKT1 Proteins) signaling and controlling p21 levels, which further modulate intimal hyperplasia and vascular smooth muscle cells proliferation
CBX3 (show CBX3 Proteins) promotes tumor proliferation by regulating G1/S phase via p21 downregulation and associates with poor prognosis in tongue squamous cell carcinoma
our data demonstrated for the first time that inhibition of RAD51 (show RAD51 Proteins) suppressed the cervical cancer cell proliferation and the growth of cervical cancer xenografts by attenuating cell cycle transition, which could be a functional link between RAD51 (show RAD51 Proteins) and cyclin D1 (show CCND1 Proteins) and p21
The results presented herein highlight the importance of p21Cip1 and p27Kip1 (show CDKN1B Proteins) in the cell cycle control and drug resistance of glioma stem cells, providing new insights into the field of glioma biology.
LncRNA-ANCR (show ube3a Proteins) inhibited the cell proliferation, migration, and invasion of osteosarcoma cells, possibly through interacting with EZH2 (show EZH2 Proteins) and regulating the expression of p21 and p27 (show PAK2 Proteins).
p21 is a bona fide ubiquitylation substrate for CHIP.p21 role in lung cancer radioresistance.
PVT1 played a pivotal part on the regulation of p21 expression in breast cancer cell lines.
Thus, the present study indicated that parkin (show PARK2 Proteins) knockout inhibits neural stem cell differentiation by JNK (show MAPK8 Proteins)-dependent proteasomal degradation of p21.
p21 expression reports on Bovine herpesvirus 4 replication and could represent a host cell defensive response to infection-associated cellular damage.
Results identify endoplasmic reticulum stress as an age-dependent modifier of islet survival and function by mechanisms implicating enhancement of CHOP (show DDIT3 Proteins) activity and inhibition of the protective activity of p21.
Specifically, the proteins p18INK4C (show CDKN2C Proteins), p21CIP1 and p27KIP1 (show CDKN1B Proteins) seem to play an outstanding role in the maintenance of the differentiated state of adipocytes.
Collectively, our findings demonstrate that PCAT-1 is a new candidate for use in OS diagnosis, prognosis and therapy.
results indicated that p21-deficient DMM (show COL2A1 Proteins) mice were susceptible to alterations in Osteoarthritis (OA) phenotype, including enhanced osteoclast expression, macrophage infiltration, and MMP expression through IL-1beta (show IL1B Proteins)-induced NF-kappaB (show NFKB1 Proteins) signaling, suggesting that p21 regulation may constitute a possible therapeutic strategy for OA treatment.
our genetic and biochemical data show an important function of p21 in the regulation of growth-related processes in the heart.
The Smad3 (show SMAD3 Proteins) and Bmal1 (show ARNTL Proteins) regulate p21 and S100A4 (show S100A4 Proteins) expression in myocardial stromal fibroblasts through TNF-alpha (show TNF Proteins).
Data suggest BAF180 (show PBRM1 Proteins) protein as a critical regulator of cellular senescence and HSC (show FUT1 Proteins) homeostasis, which is at least partially regulated through BAF180 (show PBRM1 Proteins)-mediated suppression of cell cycle regulator p21 expression.
Histone methyltransferase Suv39h1 (show SUV39H1 Proteins) attenuates high glucose-induced fibronectin (show FN1 Proteins) and p21(WAF1) in mesangial cells
It has been observed that even in tissues with no detectable Linc-p21 transcript, deletion of the locus significantly affects local gene expression, including of the cell cycle regulator Cdkn1a.
The findings suggest that p21 facilitates the development of cardiac hypertrophy, and regulating the expression of p21 may be an approach to attenuate hypertrophic growth of cardiomyocytes.
This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Multiple alternatively spliced variants have been found for this gene.
cyclin dependent kinase inhibitor p16Xic2
, cyclin-dependent kinase inhibitor 1
, cyclin D1
, cyclin-dependent kinase inhibitor 1A (p21, Cip1)
, cyclin-dependent kinase inhibitor 1A
, cyclin-dependent kinase inhibitor 1A (P21)
, CDK-interacting protein 1
, CDK-interaction protein 1
, DNA synthesis inhibitor
, melanoma differentiation associated protein 6
, wild-type p53-activated fragment 1
, melanoma differentiation-associated protein