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  • Experiment Reproducibility
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  • ELISA Kit Robustness
    The recommended assay will likely function better with approved sample types, and will not suffer from undue matrix interference than the available alternatives.
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FAS Antigen Profile

Antigen Summary

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform.

Alternative names and synonyms associated with FAS

  • Fas cell surface death receptor (FAS) ELISA Kit
  • tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta (YWHAZ) ELISA Kit
  • Fas (TNF receptor superfamily member 6) (Fas) ELISA Kit
  • Fas cell surface death receptor (Fas) ELISA Kit
  • Fas cell surface death receptor (fas) ELISA Kit
  • APO-1 ELISA Kit
  • APT1 ELISA Kit
  • CD95 ELISA Kit
  • FAS1 ELISA Kit
  • AI196731 ELISA Kit
  • APO1 ELISA Kit
  • Tnfrsf6 ELISA Kit
  • lpr ELISA Kit

Protein level used designations for FAS

APO-1 cell surface antigen , CD95 antigen , Delta Fas/APO-1/CD95 , FAS 827dupA , FASLG receptor , Fas (TNF receptor superfamily, member 6) , Fas AMA , TNF receptor superfamily member 6 , apoptosis antigen 1 , apoptosis-mediating surface antigen FAS , tumor necrosis factor receptor superfamily member 6 , tumor necrosis factor receptor superfamily, member 6 , Fas antigen , 14-3-3 protein zeta/delta , FAS , KCIP-1 , factor activating exoenzyme S , protein kinase C inhibitor protein 1 , Fas (TNF receptor superfamily member) , apo-1 antigen , lymphoproliferation , Fas antigen (ATP1) , Fas receptor , Tumor necrosis factor receptor superfamily, member 6 , apoptosis (APO-1) antigen 1 ( FAS ), member 6 , Fas receptor CD95

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