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anti-Human MAP4 Antibodies:
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Human Polyclonal MAP4 Primary Antibody for IHC - ABIN966516
Ookata, Hisanaga, Bulinski, Murofushi, Aizawa, Itoh, Hotani, Okumura, Tachibana, Kishimoto: Cyclin B interaction with microtubule-associated protein 4 (MAP4) targets p34cdc2 kinase to microtubules and is a potential regulator of M-phase microtubule dynamics. in The Journal of cell biology 1995
Show all 8 Pubmed References
Human Polyclonal MAP4 Primary Antibody for - ABIN966518
Wu, Ma, Brown, Geisler, Li, Tzeng, Jia, Jurisica, Li: Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening. in Proteomics 2007
Show all 6 Pubmed References
Mouse (Murine) Polyclonal MAP4 Primary Antibody for - ABIN966517
Olsen, Blagoev, Gnad, Macek, Kumar, Mortensen, Mann: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. in Cell 2006
Show all 6 Pubmed References
Human Polyclonal MAP4 Primary Antibody for ELISA, WB - ABIN546527
Chan, Asokan, King, Bo, Dubose, Liu, Berginski, Simon, Davis, Gomez, Sharpless, Bear: LKB1 loss in melanoma disrupts directional migration toward extracellular matrix cues. in The Journal of cell biology 2014
Human Polyclonal MAP4 Primary Antibody for ICC, IF - ABIN4332659
Stadler, Rexhepaj, Singan, Murphy, Pepperkok, Uhlén, Simpson, Lundberg: Immunofluorescence and fluorescent-protein tagging show high correlation for protein localization in mammalian cells. in Nature methods 2013
Human Polyclonal MAP4 Primary Antibody for WB - ABIN6683105
Li, Wan, Zhang, Li, Han: Quantitative proteomic analysis and comparison of two bone marrow stromal cell lines using the SILAC method. in Experimental hematology 2017
The authors propose a model for the regulation of microtubule (MT)-based transport of pigment granules in melanophores in which reversible binding of XMAP4 to MTs determines the direction of MT-based pigment granule movement.
Expression level of MAP4 mRNA and protein in lung adenocarcinoma tissues were significantly higher than those in noncancerous tissues. MAP4 expression significantly correlated with tumor progression.
Microtubule-associated protein 4 (MAP4) controls the dynein-dependent transport of BTN3A1 in response to nucleic acid stimulation, thereby identifying MAP4 as an upstream regulator of BTN3A1. Thus, the depletion of either MAP4 or BTN3A1 impairs cytosolic DNA- or RNA-mediated type I IFN responses.
an intratumoral injection of MAP4-small interfering RNA (siRNA) remarkably inhibited the growth of the tumors that formed by the MAP4-expressing ESCC cells in nude mice, and a combination of MAP4-siRNA and Bevacizumab significantly enhanced the inhibition effect. Our data suggest that MAP4 is probably a useful prognostic biomarker and a potential therapeutic target for the disease.
MAP4 acts as a checkpoint molecule that balances positive and negative hallmarks of T cell activation.
Results show that marker rs218966 in gene PHF14 and rs9836027 in MAP4 significantly associated with hypertension; additionally, rare variants in SNUPN significantly associated with systolic blood pressure.
We demonstrated that the MAP4 (Ser696 and Ser787) phosphorylation increased concomitantly with the p38/MAPK pathway activation by the LPS and TNF-alpha stimulation of HPMECs, which induced MT disassembly followed by hyperpermeability.
Results demonstrated that MAP4 mutations contribute to the clinical spectrum of centrosomal defects and confirmed the complex role of a centrosomal protein in centrosomal, ciliary, and Golgi regulation associated with severe short stature.
Data show that cAMP/alpha isoform of the catalytic subunit of human PKA (PKAc-alpha) signaling can disrupt microtubule (MT) cytoskeleton by the phosphorylation of microtubule-Associated Protein 4 (MAP4).
MAP4, which is a binding partner of SEPT2.
there are two possible mechanisms triggered by MAP4: stabilization of MT networks; DYNLT1 modulation, which is connected with VDAC1, and inhibition of hypoxia-induced mitochondrial permeabilization
DNAL1 and MAP4 may exert their functions in the HIV life cycle at reverse transcription, prior to nuclear translocation.
Data show that the tau-related protein MAP4 and the microtubule rescue factor CLASP1 are essential for maintaining spindle position and the correct cell-division axis.
Results suggest that structural features of the PJ domain of MAP4 may contribute to the formation of a radial array of microtubules in proliferating cells.
demonstrate that ectopic MAP4 promotes outgrowth of extended MTs during beta1-integrin-induced cell spreading
activity of MAP4 is downregulated by reduced free tubulin concentrations
adenovirus 2 E1B-55K protein blocks p53 as a transcriptional repressor protein of the survivin and the MAP4 promoters
MAP4 microtubule decoration interferes with beta-adrenergic receptor recycling and that this may be one mechanism for beta-adrenergic receptor downregulation in heart failure.
Truncation of the projection domain of MAP4 leads to attenuation of microtubule dynamic instability.
mAP4 interaction with septins modulates microtubule dynamics.
This first report of a genetic alteration involving MAP4 points to a potentially relevant target gene in diffuse large B-cell lymphoma.
A novel isoform of MAP4 organizes the paraxial microtubule array required for muscle cell differentiation.
This study suggested that The results suggest that MAP4 play roles in some neuron-specific events, such as the dynamic cytoskeletal reorganization and regulation of the microtubule-dependent long-range transport.
Basis for MAP4 dephosphorylation-related microtubule network densification in pressure overload cardiac hypertrophy.
Data indicate that MAP4 binding alters the properties of the actin filaments.
the role of the MAP4 isoforms is to regulate the surface charge of microtubules
A neural cell-specific variant of MAP4 was identified; an ultrastructural study was also made.
The protein encoded by this gene is a major non-neuronal microtubule-associated protein. This protein contains a domain similar to the microtubule-binding domains of neuronal microtubule-associated protein (MAP2) and microtubule-associated protein tau (MAPT/TAU). This protein promotes microtubule assembly, and has been shown to counteract destabilization of interphase microtubule catastrophe promotion. Cyclin B was found to interact with this protein, which targets cell division cycle 2 (CDC2) kinase to microtubules. The phosphorylation of this protein affects microtubule properties and cell cycle progression. Multiple transcript variants encoding different isoforms have been found for this gene.
microtubule-associated protein 4
, MAP 4
, microtubule associated protein 4
, microtubule-associated protein U