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Human MDM2 Protein expressed in Wheat germ - ABIN1310600
Zhang, Zhong, Chen: LC-MS/MS-based targeted proteomics quantitatively detects the interaction between p53 and MDM2 in breast cancer. in Journal of proteomics 2016
The MDM2 Del1518 polymorphism (rs3730485) was associated with breast cancer susceptibility, particularly in menopausal patients with breast cancer who reported tobacco consumption, pregnancy loss, obesity and high glucose levels in Mexican population.
study showed that UVB induces alternative splicing of hdm2 by increasing the expression and the binding of hnRNP A1 (show HNRNPA1 Proteins) to hdm2 full-length mRNA
in colon cancer cell migration, activin utilizes NFkB to induce MDM2 activity leading to the degradation of p21 (show CDKN1A Proteins) in a PI3K (show PIK3CA Proteins) dependent mechanism
Author demonstrated that LRRK2 increases the expression of p53 and p21 by increasing the Mdm2 phosphorylation in response to DNA damage. Loss-of-function in LRRK2 has the opposite effect to that of LRRK2.
Relevant SNPs in DNA repair (ERCC1 (show ERCC1 Proteins) and ERCC5 (show ERCC5 Proteins)) and apoptosis (MDM2 and TP53 (show TP53 Proteins)) genes might influence the severity of radiation-related side-effects in HNSCC patients. Prospective clinical SNP-based validation studies are needed on these bases
this is the first documentation of MDM2 amplification in laryngeal/hypopharyngeal well-differentiated liposarcomas
The MDM2 309GG genotype was associated with higher risk of preeclampsia.
A meta-analysis of case-control studies found that MDM2 rs2279744 (SNP309) and rs117039649 (SNP285) were both associated with the risk of gynecological cancers. Subgroup analysis showed that rs2279744 (SNP309) was associated with the risk of gynecological cancers in Caucasian and Asian according to the ethnicity and cancer type, especially for endometrial cancer.
we here show that subgroups of SDCs display genomic amplifications of MDM2 and/or CDK4, partly in association with TP53 mutations and rearrangement/amplification of HMGA2.
Estradiol treatment increases hnRNPA1 (show HNRNPA1 Proteins) level and then reduces the expression of MDM2 to prevent cell proliferation, migration and epithelial-mesenchymal transition in skin tumor cells.
results suggest overexpression of MDM2 is closely linked to inhibition of p53 (show TP53 Proteins)-dependent apoptosis of Theileria parva (show PARVA Proteins)-infected lymphocytes; aberrant expression of host lymphocyte MDM2 induced by cytoplasmic existence of T. parva (show PARVA Proteins), directly and/or indirectly, is associated with aspects of this type of transformation of T. parva (show PARVA Proteins)-infected lymphocytes
mutant Mdm2 was unable to rescue a p53 (show TP53 Proteins)-induced apoptotic phenotype.
Data indicate that knockdown of the Mdm2 and Mdm4 (show MDM4 Proteins) caused dramatic accumulation of mutant p53 protein (show TP53 Proteins).
Together with p53 (show TP53 Proteins), provides an experimental model for characterizing drugs and genes that affect p53 (show TP53 Proteins) signaling.
Data show that liver-specific expression of p53 (show TP53 Proteins)-negative regulator mdm2 leads to growth retardation and fragile liver in zebrafish.
c-Abl (show ABL1 Proteins) phosphorylation of Mdm2 has a role in regulation of p53 (show TP53 Proteins) tumor suppression and bone marrow failure
Bre (show BRE Proteins) enhances osteoblastic differentiation by promoting the Mdm2-mediated degradation of p53 (show TP53 Proteins).
genetic and biochemical data support a role for Mdm2 in cardiac growth control through the regulation of p53 (show TP53 Proteins), the Pgc-1 family of transcriptional coactivators and the pivotal antioxidant Pink1 (show PINK1 Proteins)
The availability of large-scale genomic profiling datasets, like those from The Cancer Genome Atlas Research Network, have provided the opportunity to evaluate the consequences of MDM2 amplification and SNP inheritance across high-quality tumor samples from diverse cancer indications. [review]
findings document contrasting effects of ATM (show ATM Proteins)-Mdm2 signaling on p53 (show TP53 Proteins) tumor suppression and reveal that destabilizing Mdm2 by promoting its phosphorylation by ATM (show ATM Proteins) would be effective in treating oncogene (show RAB1A Proteins)-induced malignancies.
the existence of an unusual functional interplay between STATs and CREB (show CREB1 Proteins) at the onset of adipogenesis through shared CRTC cofactors, is reported.
Mdm2 expression is required for cell survival even in the absence of p53 (show TP53 Proteins). Moreover, results suggest that p73 (show ARHGAP24 Proteins) compensates for loss of p53 (show TP53 Proteins).
In Fmr1 (show FMR1 Proteins) KO neurons, Mdm2 is hyperphosphorylated, nuclear localized basally, and unaffected by MEF2 (show MEF2C Proteins) activation, which our data suggest due to an enhanced interaction with Eukaryotic Elongation Factor (show TSFM Proteins) 1alpha (EF1alpha), whose protein levels are elevated in Fmr1 (show FMR1 Proteins) KO. Expression of a dephosphomimetic of Mdm2 rescues PSD-95 (show DLG4 Proteins) ubiquitination, degradation and synapse elimination in Fmr1 (show FMR1 Proteins) KO neurons.
MDM2 is a non-redundant survival factor for proximal tubular cells by protecting them from spontaneous p53 (show TP53 Proteins) overexpression-related cell death.
The case emphasizes that MDM2 expression represents a possible pitfall in the diagnosis of spindle cell tumors. The differential diagnostic distinction between FDCS and a dedifferentiated liposarcoma is discussed.
This gene is a target gene of the transcription factor tumor protein p53. The encoded protein is a nuclear phosphoprotein that binds and inhibits transactivation by tumor protein p53, as part of an autoregulatory negative feedback loop. Overexpression of this gene can result in excessive inactivation of tumor protein p53, diminishing its tumor suppressor function. This protein has E3 ubiquitin ligase activity, which targets tumor protein p53 for proteasomal degradation. This protein also affects the cell cycle, apoptosis, and tumorigenesis through interactions with other proteins, including retinoblastoma 1 and ribosomal protein L5. More than 40 different alternatively spliced transcript variants have been isolated from both tumor and normal tissues.
E3 ubiquitin-protein ligase Mdm2
, Mdm2, p53 E3 ubiquitin protein ligase homolog
, Mdm2, transformed 3T3 cell double minute 2, p53 binding protein
, double minute 2, human homolog of; p53-binding protein
, oncoprotein Mdm2
, Mdm2 p53 binding protein homolog
, double minute 2 protein
, p53-binding protein Mdm2
, MDM2 alpha
, double minute 2 homolog
, double minute 2
, MDM2-like protein
, transformed mouse 3T3 cell double minute 2
, murine double minute 2 homolog