Browse our anti-ENPEP (ENPEP) Antibodies

Zebrafish Glutamyl Aminopeptidase (Aminopeptidase A) (ENPEP) interaction partners

1. Study describes a zebrafish 2 kb glutamyl aminopeptidase (enpep) promoter fragment, and shows that it can drive gene expression specifically in the kidney during early and late development.

Mouse (Murine) Glutamyl Aminopeptidase (Aminopeptidase A) (ENPEP) interaction partners

1. de-regulation of both PITX2 and ENPEP could contribute to an increased risk of atrial fibrillation in carriers of disease-associated variants.

2. Demonstrate a novel role of APA in ANG-(1-7) metabolism and suggest that the upregulation of APA, which occurs after myocardial infarction, may deprive the heart of cardioprotective ANG-(1-7).

3. Ischemia-induced angiogenesis is impaired in APA-KO mice partly through decreased HIF-1alpha stability by proteasomal degradation and subsequent suppression of HIF-1alpha-driven target protein expression such as growth factors.

4. dietary fatty acids affect activity in moue testis

5. Replacement of active site residue glutamate-215 of aminopeptidase A with aspartate or alanine leads to a strong decrease in the rate of hydrolysis of the synthetic substrate alpha-L-glutamyl-beta-naphthylamide.

6. the C-terminal domain of aminopeptidase A acts as an intramolecular chaperone

7. Lack of angiotensin II conversion to angiotensin III increases water but not alcohol consumption in aminopeptidase A-deficient mice.Elevated central concentrations of the vasopressor octapeptide angiotensin (Ang) II increase the water intake in mammals.

8. Results demonstrate a key role of Thr-348 in substrate specificity of aminopeptidase A for N-terminal acidic amino acids by insuring the optimal positioning of the substrate during catalysis.

Human Glutamyl Aminopeptidase (Aminopeptidase A) (ENPEP) interaction partners

1. We suggest that APA enzymatic activity affects tumor initiation and cancer malignancy in a TWIST-dependent manner

2. The substrate Angiotensin II, the enzymes aminopeptidases-A, B, M as well as IRAP were detected in the jejunal mucosa.

3. This study suggests a role for GAP in the neoplastic development of renal tumours and provides additional data for considering the activity and expression of this enzyme of interest in the diagnosis and prognosis of renal neoplasms.

4. miR-125b acts as a tumor suppressor in breast tumorigenesis via its novel direct targets ENPEP, CK2-alpha, CCNJ, and MEGF9.

5. These results explain the calcium-modulated substrate specificity of APA in central hypertension regulation

6. There was no significant alteration in plasma APA activity in the patients with Chagas disease or dilated cardiomyopathies, as compared with that in health controls

7. Rieger syndrome with microdeletions including only the PITX2 and ENPEP (glutamyl aminopeptidase) genes.

8. Data show that APA appears to be an essential enzyme in the control of blood pressure via degradation of Angiotensin II.

9. Data show that aminopeptidase A (APA) plays important roles in the regulation of blood pressure under both the physiological and pathological conditions.

10. Data show that brain aminopeptidases act upon Ang I, Ang II and Ang III in order to activate brain AT(1) receptors.

11. rare and common variation in ENPEP may contribute to the development of renal and hypertensive disorders and warrants further study

12. The presence of APA in several human brain nuclei sensitive to angiotensins and involved in blood pressure regulation suggests that APA in humans is an integral component of the brain renin angiotensin system.

13. A novel nonsense polymorphism in the aminopeptidase-a gene was associated with hypertension among postmenopausal women, and those with marginal calcium and vitamin D intake.

14. Angiotensin III and aminopeptidase A and N, related converting enzymes, contribute to cell proliferation of prostate cancer and may be implicated in cancer progression.

15. Over-expressed APA drastically reduces, in a calcium dependent manner, full-length-Abeta but not amyloid-beta precursor protein (APP) intracellular domain in a cell-free model of Abeta production.

16. The activity of glutamyl aminopeptidase was significally increased in head and neck squamous cell carcinoma tissue.