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Ablation of the GNB3 gene in mice does not affect body weight, metabolism or blood pressure, but causes bradycardia.
A transgenic model carries an extra copy of GNB3, weighs significantly more than wild-type littermates, and has excess fat accumulation. GNB3 is highly expressed in the brain, consistent with G-protein signaling involved in satiety and/or metabolism.
These results suggest that the main role of Gbeta3 in cones is to establish optimal levels of transducin (show GNAT1 Proteins) heteromer in the outer segment, thereby indirectly contributing to robust response properties.
The results of this study showed that Gbeta (show SUCLG2 Proteins)(3) may play a role in synaptic maintenance since in its absence, the number of invaginating rod bipolar dendrites is greatly reduced, a deficit that was not observed at 3 weeks, the end of the developmental period.
Gbeta3 subunit is coexpressed in physiologically ON-type cone bipolar cells with Ggamma13 (show GNg13 Proteins) and Gbeta4 but is not present in OFF-type bipolar cells.
Our study indicates that variations in OXTR (show OXTR Proteins) and Gbeta3 genes are specifically associated with presence and severity of Separation Anxiety in childhood and adulthood, but not with depression or anxiety in general.
Our results demonstrate the potential use of a GNB3-specific antisense morpholino, as a pharmacogenetic therapy for essential hypertension
No relationship was found between the studied polymorphisms (14094 ACE (show ACE Proteins) gene, rs1800469 gene TGFbeta1 (show TGFB1 Proteins), GNB3 gene rs5443, rs5186 AGTR1 (show AGTR1 Proteins) gene) and the occurrence of primary vesicoureteral reflux. TT genotype polymorphism rs5443 of the GNB3 gene may be a protective factor for improved renal function in patients with primary vesicoureteral reflux.
Interactions between GNB3, CREB1 (show CREB1 Proteins) and negative life events were revealed. Further evidence is provided about the role of the environment in genetic vulnerability to major depression.
Bipolar patients with the TT genotype had a lower BMI, smaller waist circumference, and lower levels of lipids and leptin (show LEP Proteins) than those with the CT or CC genotypes undergoing the valproic acid treatment course.
Mutational analysis of GNB3 in a cohort of 58 subjects with CSNB (show CSN2 Proteins) identified a sporadic case individual with a homozygous GNB3 mutation
The GNB3 TT genotype is a risk factor for coronary artery disease independent of other established cardiovascular risk factors in Chinese hypertensive patients.
The combined effects of ACE (show ACE Proteins) and GNB3 polymorphisms showed that no pulmonary hypertension patients with the ACE (show ACE Proteins)/GNB3 II/TT genotype exhibited clinical worsening.
Although not statistically significant, women who carried the GNB3 T risk allele gained 6 pounds more than noncarriers, and mean 6-month postpartum BMI differed by 2.2 kg/m(2) between homozygous women
GNB3 C825T polymorphisms may be correlated with the efficacy of antidepressants in the treatment of MDD, especially among Asians patients.
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction.
guanine nucleotide binding protein (G protein), beta polypeptide 3
, Transducin beta chain 3
, guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
, guanine nucleotide binding protein, beta 3
, transducin beta chain 3
, G protein, beta-3 subunit
, GTP-binding regulatory protein beta-3 chain
, guanine nucleotide-binding protein G(I)/G(S)/G(T) beta subunit 3
, hypertension associated protein
, GTP-binding protein beta-3 subunit short isoform
, transducin beta-3-subunit
, G protein beta-subunit
, guanine nucleotide binding protein (G protein), beta 3
, guanine nucleotide-binding protein, beta-3 subunit