GNB3 Protein (AA 1-340) (His tag)

Catalog No. ABIN5853311

Product Details

Target: GNB3 (Guanine Nucleotide Binding Protein (G Protein), beta Polypeptide 3 (GNB3))

Protein Type: Recombinant

Protein Characteristics: AA 1-340

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This GNB3 protein is labelled with His tag.

Application: SDS-PAGE (SDS)

Sequence: MGSSHHHHHH SSGLVPRGSH MGSMGEMEQL RQEAEQLKKQ IADARKACAD VTLAELVSGL EVVGRVQMRT RRTLRGHLAK IYAMHWATDS KLLVSASQDG KLIVWDSYTT NKVHAIPLRS SWVMTCAYAP SGNFVACGGL DNMCSIYNLK SREGNVKVSR ELSAHTGYLS CCRFLDDNNI VTSSGDTTCA LWDIETGQQK TVFVGHTGDC MSLAVSPDFN LFISGACDAS AKLWDVREGT CRQTFTGHES DINAICFFPN GEAICTGSDD ASCRLFDLRA DQELICFSHE SIICGITSVA FSLSGRLLFA GYDDFNCNVW DSMKSERVGI LSGHDNRVSC LGVTADGMAV ATGSWDSFLK IWN

Purity: > 80 % by SDS - PAGE

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

Denatured

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Liquid. 20  mM Tris-HCl buffer (  pH 8.0) containing 10 % glycerol 0.4M urea

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.

Target Details

Target: GNB3 (Guanine Nucleotide Binding Protein (G Protein), beta Polypeptide 3 (GNB3))

Alternative Name: GNB3 (GNB3 Products)

Synonyms: Gnb-3 Protein, MGC68913 Protein, MGC130764 Protein, gnb3 Protein, zgc:73058 Protein, zgc:77780 Protein, wu:fk54b04 Protein, gnb3l Protein, zgc:92641 Protein, G protein subunit beta 3 Protein, guanine nucleotide binding protein (G protein), beta 3 Protein, guanine nucleotide binding protein (G protein), beta polypeptide 3 S homeolog Protein, guanine nucleotide binding protein (G protein), beta polypeptide 3b Protein, guanine nucleotide binding protein (G protein), beta polypeptide 3a Protein, GNB3 Protein, Gnb3 Protein, gnb3.S Protein, gnb3b Protein, gnb3a Protein

Background: GNB3 is important regulator of alpha subunit, as well as of certain signal transduction receptor and effector. A single-nucleotide polymorphism (C825T) in this protein is associated with essential hypertension and obesity. This polymorphism is also associated with the occurrence of the splice variant GNB3-s, which appears to have increased activity. GNB3-s is an example of alternative splicing caused by a nucleotide change outside of the splice donor and acceptor sites. Additional splice variants may exist for this gene, but they have not been fully described. Recombinant human GNB3 protein, fused to His-tag at N-terminus, was expressed in E.coli.

Molecular Weight: 39.6 kDa(363aa)

NCBI Accession: NP_002066

UniProt: P16520

Pathways: Peptide Hormone Metabolism, Myometrial Relaxation and Contraction