Charged Multivesicular Body Protein 5 (CHMP5) (C-Term) Peptide
CHMP5
Reactivity: Human, Mouse
Host: Synthetic
BP, WB
Catalog No. ABIN1541428
Quick Overview for Charged Multivesicular Body Protein 5 (CHMP5) (C-Term) Peptide (ABIN1541428)
Target
CHMP5
(Charged Multivesicular Body Protein 5 (CHMP5))
Origin
Human, Mouse
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- C-Term
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Sequence
- Synthetic peptide located within the following region: < a href='http://www.ncbi.nlm.nih.gov/blast/Blast.cgi?PROGRAM=blastp&CLIENT=web&SERVICE=plain&PAGE=Proteins&CMD=Put&DATABASE=nr&CDD_SEARCH=1&AUTO_FORMAT=Semi-auto&SHOW_OVERVIEW=on&SHOW_LINKOUT=on&GET_SEQUENCE=on&NCBI_GI=on&ALIGNMENTS =50&I_THRESH=0.005&QUERY=
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-Chmp5 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Charged Multivesicular Body Protein 5 (CHMP5) peptide
CHMP5 Reactivity: Human, Mouse, Cow, Rat Host: Synthetic BP, Imm
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- CHMP5 (Charged Multivesicular Body Protein 5 (CHMP5))
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Background
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Chmp5 is a probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis. ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4.
Alias Symbols: 2210412K09Rik, AW545668
Protein Size: 219 -
Molecular Weight
- 24 kDa
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Gene ID
- 76959
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NCBI Accession
- NM_029814, NP_084090
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UniProt
- Q9D7S9
Target
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