Vitamin D Receptor (VDR) (N-Term) Peptide
VDR
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN1542380
Quick Overview for Vitamin D Receptor (VDR) (N-Term) Peptide (ABIN1542380)
Target
Vitamin D Receptor (VDR)
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- N-Term
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Sequence
- LKRKEEEALK DSLRPKLSEE QQRIIAILLD AHHKTYDPTY SDFCQFRPPV
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-VDR Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Vitamin D Receptor (VDR) peptide
VDR Reactivity: Human, Mouse, Rat, Dog Host: Synthetic BP, Imm
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Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Vitamin D Receptor (VDR)
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Target Type
- Chemical
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Background
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The nuclear hormone receptor for vitamin D3 also functions as a receptor for the secondary bile acid lithocholic acid. The receptor belongs to the family of trans-acting transcriptional regulatory factors and shows sequence similarity to the steroid and thyroid hormone receptors. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternative splicing results in multiple transcript variants encoding the same protein.
Alias Symbols: NR1I1
Protein Interaction Partner: CDK7,GTF2B,KDM5A,NCOA1,NCOA2,NCOA3,RXRA,SMAD3,ACVR1,BAG1,CCND3,CDK7,CREBBP,CSNK2A1,FGR,GABARAPL1,GABARAPL2,GTF2B,HMGN3,HR,JUN,KDM5A,MED1,NCOA1,NCOA2,NCOA6,NR0B2,NR1H2,NRIP1,PPP1CA,PPP2CA,PSMC5,RXRA,RXRB,RXRG,SMAD3,SNW1,SNW1,STAT1,TDG,TRIM24,VDR,ZBTB16,BAG
Protein Size: 427 -
Molecular Weight
- 48 kDa
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Gene ID
- 7421
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NCBI Accession
- NM_000376, NP_000367
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UniProt
- P11473
Target
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