Amyloid beta (Abeta) (AA 1-42) Peptide
Abeta
Reactivity: Human
Host: Synthetic
Catalog No. ABIN2017638
Quick Overview for Amyloid beta (Abeta) (AA 1-42) Peptide (ABIN2017638)
Target
beta Amyloid (Abeta)
(Amyloid beta (Abeta))
Origin
Human
Source
Synthetic
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Protein Region
- AA 1-42
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Sequence
- DAEFRHDSGY EVHHQKLVFF AEDVGSNKGA IIGLMVGGVV IA
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Specificity
- Formula: C203H311N55O60S1
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Characteristics
- This peptide is well suited to the quantitative determination of A 42 peptide. Alzheimer's disease (AD) is characterized by the presence of extracellular plaques and intracellular neurofibrillary tangles (NFTs) in the brain. The major protein component of these plaques is beta amyloid peptide (A), a 40- to 43- amino-acid peptide cleaved from amyloid precursor protein by secretase (BACE) and a putative (gamma) secretase. Increased release of the 'longer forms' of A peptide, A 42 and A 43, which have a greater tendency to aggregate than A 40, occurs in individuals expressing certain genetic mutations, expressing certain ApoE alleles or may other, still undiscovered factors.
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Purity
- > 95 %
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Restrictions
- For Research Use only
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Reconstitution
- Insoluble in water, may be dissolved in any buffer of pH >9.
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Storage
- -20 °C
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- beta Amyloid (Abeta) (Amyloid beta (Abeta))
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Molecular Weight
- 4514.100 kDa
Target
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