Amyloid beta (Abeta) (AA 1-42) Peptide
Abeta
Reactivity: Human
Host: Synthetic
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- Target See all beta Amyloid (Abeta) products
- beta Amyloid (Abeta) (Amyloid beta (Abeta))
- Protein Region
- AA 1-42
- Origin
- Human
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Source
- Synthetic
- Sequence
- DAEFRHDSGY EVHHQKLVFF AEDVGSNKGA IIGLMVGGVV IA
- Specificity
- Formula: C203H311N55O60S1
- Characteristics
- This peptide is well suited to the quantitative determination of A 42 peptide. Alzheimer's disease (AD) is characterized by the presence of extracellular plaques and intracellular neurofibrillary tangles (NFTs) in the brain. The major protein component of these plaques is beta amyloid peptide (A), a 40- to 43- amino-acid peptide cleaved from amyloid precursor protein by secretase (BACE) and a putative (gamma) secretase. Increased release of the 'longer forms' of A peptide, A 42 and A 43, which have a greater tendency to aggregate than A 40, occurs in individuals expressing certain genetic mutations, expressing certain ApoE alleles or may other, still undiscovered factors.
- Purity
- > 95 %
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- Restrictions
- For Research Use only
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- Reconstitution
- Insoluble in water, may be dissolved in any buffer of pH >9.
- Storage
- -20 °C
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- Target
- beta Amyloid (Abeta) (Amyloid beta (Abeta))
- Molecular Weight
- 4514.100 kDa
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