Telomerase Reverse Transcriptase (TERT) (C-Term) Peptide
TERT
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN2182269
Quick Overview for Telomerase Reverse Transcriptase (TERT) (C-Term) Peptide (ABIN2182269)
Target
TERT
(Telomerase Reverse Transcriptase (TERT))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- C-Term
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Sequence
- HQAFLLKLTR HRVTYVPLLG SLRTAQTQLS RKLPGTTLTA LEAAANPALP
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-TERT Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeat freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- TERT (Telomerase Reverse Transcriptase (TERT))
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Background
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Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified, the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity.
Alias Symbols: DKCA2, DKCB4, EST2, TCS1, TP2, TRT, hEST2, hTRT
Protein Size: 1132 -
Molecular Weight
- 127 kDa
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Gene ID
- 7015
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NCBI Accession
- NM_198253, NP_937983
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UniProt
- O14746
Target
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