Cytochrome B-245, beta Polypeptide (CYBB) (C-Term) Peptide
CYBB
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all CYBB products
- CYBB (Cytochrome B-245, beta Polypeptide (CYBB))
- Protein Region
- C-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- DNEFKTIASQ HPNTRIGVFL CGPEALAETL SKQSISNSES GPRGVHFIFN
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-CY24B Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeat freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- CYBB (Cytochrome B-245, beta Polypeptide (CYBB))
- Background
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Cytochrome b (-245) is composed of cytochrome b alpha (CYBA) and beta (CYBB) chain. It has been proposed as a primary component of the microbicidal oxidase system of phagocytes. CYBB deficiency is one of five described biochemical defects associated with chronic granulomatous disease (CGD). In this disorder, there is decreased activity of phagocyte NADPH oxidase, neutrophils are able to phagocytize bacteria but cannot kill them in the phagocytic vacuoles. The cause of the killing defect is an inability to increase the cell's respiration and consequent failure to deliver activated oxygen into the phagocytic vacuole.
Alias Symbols: CYBB,NOX2,
Protein Size: 570 - Molecular Weight
- 62 kDa
- Gene ID
- 1536
- NCBI Accession
- NP_000388
- UniProt
- P04839
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