Caspase 3 (CASP3) (Middle Region) Peptide
CASP3
Reactivity: Human, Mouse
Host: Synthetic
BP, WB
Catalog No. ABIN2184909
Quick Overview for Caspase 3 (CASP3) (Middle Region) Peptide (ABIN2184909)
Target
Caspase 3 (CASP3)
Origin
Human, Mouse
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- Middle Region
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Sequence
- LTGKPKLFII QACRGTELDC GIETDSGTDE EMACQKIPVE ADFLYAYSTA
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-Casp3 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeat freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Caspase 3 (CASP3)
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Background
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Casp3 is involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond, cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain, cleaves and activates caspase-6, -7 and -9, triggers cell adhesion in sympathetic neurons through RET cleavage, cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes.
Alias Symbols: A830040C14Rik, AC-3, Apopain, CC3, CPP32, Caspase-3, Lice, Yama, mldy
Protein Size: 277 -
Molecular Weight
- 31 kDa
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Gene ID
- 12367
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NCBI Accession
- NM_009810, NP_033940
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UniProt
- P70677
Target
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