Folliculogenesis Specific Basic Helix-Loop-Helix (FIGLA) (C-Term) Peptide
FIGLA
Reactivity: Human, Mouse
Host: Synthetic
BP, WB
Catalog No. ABIN2185022
Quick Overview for Folliculogenesis Specific Basic Helix-Loop-Helix (FIGLA) (C-Term) Peptide (ABIN2185022)
Target
FIGLA
(Folliculogenesis Specific Basic Helix-Loop-Helix (FIGLA))
Origin
Human, Mouse
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- C-Term
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Sequence
- SSTRELLGNA TQPTSCASGL KKEEEGPWAY AGHSEPLYSY HQSTVPETRS
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-Figla Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Handling Advice
- Avoid repeat freeze-thaw cycles.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- FIGLA (Folliculogenesis Specific Basic Helix-Loop-Helix (FIGLA))
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Background
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Figla is a germ-line specific transcription factor implicated in postnatal oocyte-specific gene expression. It plays a key regulatory role in the expression of multiple oocyte-specific genes, including those that initiate folliculogenesis and those that encode the zona pellucida (ZP1, ZP2 and ZP3) required for fertilization and early embryonic survival. It is essential for oocytes to survive and form primordial follicles. The persistence of FIGLA in adult females suggests that it may regulate additional pathways that are essential for normal ovarian development. Figla binds to the E-box (5'-CANNTG-3') of the ZPs (ZP1, ZP2, ZP3) promoters.
Alias Symbols: bHLHc8
Protein Size: 194 -
Molecular Weight
- 21 kDa
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Gene ID
- 26910
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NCBI Accession
- NM_012013, NP_036143
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UniProt
- O55208
Target
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