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Muscleblind-Like 2 (MBNL2) (Middle Region) Peptide

MBNL2 Reactivity: Human, Rat Host: Synthetic BP, WB

Catalog No. ABIN2185652

Quick Overview for Muscleblind-Like 2 (MBNL2) (Middle Region) Peptide (ABIN2185652)

Target

MBNL2 (Muscleblind-Like 2 (MBNL2))

Origin

Human, Rat

Source

Synthetic

Application

Blocking Peptide (BP), Western Blotting (WB)

Protein Region

Middle Region

Sequence

IACFDSLKGR CSRENCKYLH PPTHLKTQLE INGRNNLIQQ KTAAAMLAQQ

Characteristics

This is a synthetic peptide designed for use in combination with anti-Mbnl2 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.

Purification

Purified
Muscleblind-Like 2 (MBNL2) peptide
MBNL2 Reactivity: Mammalian Host: Synthetic BP, WB, IHC

Muscleblind-Like 2 (MBNL2) (N-Term) peptide
MBNL2 Reactivity: Human Host: Synthetic BP, WB

Muscleblind-Like 2 (MBNL2) peptide
MBNL2 Reactivity: Human Host: Synthetic BP, WB

Application Notes

Optimal working dilution should be determined by the investigator.

Restrictions

For Research Use only
Format

Lyophilized

Reconstitution

Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.

Concentration

1 mg/mL

Buffer

Final peptide concentration is 1 mg/mL in PBS.

Handling Advice

Avoid repeat freeze-thaw cycles.

Storage

-20 °C

Storage Comment

For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
Target

MBNL2 (Muscleblind-Like 2 (MBNL2))

Background

Mbnl2 mediates pre-mRNA alternative splicing regulation. It acts either as activator or repressor of splicing on specific pre-mRNA targets. It inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. It antagonizes the alternative splicing activity pattern of CELF proteins. RNA-binding protein that binds to 5'ACACCC-3' core sequence, termed zipcode, within the 3'UTR of ITGA3. It binds to CUG triplet repeat expansion in myotonic dystrophy muscle cells by sequestering the target RNAs. It seems to regulate expression and localization of ITGA3 by transporting it from the nucleus to cytoplasm at adhesion plaques. It may play a role in myotonic dystrophy pathophysiology (DM).

Protein Size: 378

Molecular Weight

41 kDa

Gene ID

680445

UniProt

F2Z3T4

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