(1 reference)-
- Target See all beta Amyloid (Abeta) products
- beta Amyloid (Abeta) (Amyloid beta (Abeta))
- Protein Region
- AA 25-35
- Purity
- > 95 %
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- Restrictions
- For Research Use only
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- Storage
- -20 °C
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: "In vitro antiamyloidogenic properties of 1,4-naphthoquinones." in: Biochemical and biophysical research communications, Vol. 400, Issue 1, pp. 169-74, (2010) (PubMed).
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: "In vitro antiamyloidogenic properties of 1,4-naphthoquinones." in: Biochemical and biophysical research communications, Vol. 400, Issue 1, pp. 169-74, (2010) (PubMed).
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- Target
- beta Amyloid (Abeta) (Amyloid beta (Abeta))
- Background
- Beta-amyloid protein (Abeta), a major component of senile plaques of Alzheimer's disease (AD) in the brain, causes elevation of the intracellular free Ca2+ level and the production of robust free radicals. Beta-amyloid 25-35 induced apoptosis, characterized by decreased cell viability, neuronal DNA condensation, and fragmentation, is associated with an increase in intracellular free Ca2+ level, the accumulation of reactive oxygen species (ROS), and the activation of caspase-3. All of these effects induced by beta-amyloid 25-35 are reversed by genistein.
- CAS-No
- 131602-53-4
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