Proopiomelanocortin (POMC) (Middle Region) Peptide
POMC
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN5511013
Quick Overview for Proopiomelanocortin (POMC) (Middle Region) Peptide (ABIN5511013)
Target
POMC
(Proopiomelanocortin (POMC))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- Middle Region
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Sequence
- WCLESSQCQD LTTESNLLEC IRACKPDLSA ETPMFPGNGD EQPLTENPRK
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Characteristics
- This is a synthetic peptide designed for use in combination with anti- POMC Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- POMC (Proopiomelanocortin (POMC))
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Background
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This gene encodes a preproprotein that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the preproprotein and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used, adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. The antimicrobial melanotropin alpha peptide exhibits antibacterial and antifungal activity. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described.
Alias Symbols: LPH, MSH, NPP, POC, ACTH, CLIP
Protein Size: 267 -
Gene ID
- 5443
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NCBI Accession
- NM_000939, NP_000930
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UniProt
- P01189
Target
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