Coagulation Factor XIII, A1 Polypeptide (F13A1) (N-Term) Peptide
F13A1
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN5511108
Quick Overview for Coagulation Factor XIII, A1 Polypeptide (F13A1) (N-Term) Peptide (ABIN5511108)
Target
F13A1
(Coagulation Factor XIII, A1 Polypeptide (F13A1))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- N-Term
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Sequence
- LPTVELQGVV PRGVNLQEFL NVTSVHLFKE RWDTNKVDHH TDKYENNKLI
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Characteristics
- This is a synthetic peptide designed for use in combination with anti- F13A1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- F13A1 (Coagulation Factor XIII, A1 Polypeptide (F13A1))
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Background
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This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits, and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion.
Alias Symbols: F13A
Protein Size: 732 -
Gene ID
- 2162
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NCBI Accession
- NM_000129, NP_000120
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UniProt
- P00488
Target
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