Programmed Cell Death 6 Interacting Protein (PDCD6IP) (C-Term) Peptide
PDCD6IP
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all ALIX (PDCD6IP) products
- ALIX (PDCD6IP) (Programmed Cell Death 6 Interacting Protein (PDCD6IP))
- Protein Region
- C-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- QMPMPMGYNP YAYGQYNMPY PPVYHQSPGQ APYPGPQQPS YPFPQPPQQS
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-PDC6I Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- ALIX (PDCD6IP) (Programmed Cell Death 6 Interacting Protein (PDCD6IP))
- Background
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This gene encodes a protein that functions within the ESCRT pathway in the abscission stage of cytokinesis, in intralumenal endosomal vesicle formation, and in enveloped virus budding. Studies using mouse cells have shown that overexpression of this protein can block apoptosis. In addition, the product of this gene binds to the product of the PDCD6 gene, a protein required for apoptosis, in a calcium-dependent manner. This gene product also binds to endophilins, proteins that regulate membrane shape during endocytosis. Overexpression of this gene product and endophilins results in cytoplasmic vacuolization, which may be partly responsible for the protection against cell death. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. Related pseudogenes have been identified on chromosome 15.
Alias Symbols: PDCD6IP,AIP1, ALIX, KIAA1375,
Protein Size: 868 - Gene ID
- 10015
- NCBI Accession
- NP_037506
- UniProt
- Q8WUM4
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