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Programmed Cell Death 6 Interacting Protein (PDCD6IP) (C-Term) Peptide

PDCD6IP Reactivity: Human Host: Synthetic BP, WB

Catalog No. ABIN5511166

Quick Overview for Programmed Cell Death 6 Interacting Protein (PDCD6IP) (C-Term) Peptide (ABIN5511166)

Target

ALIX (PDCD6IP) (Programmed Cell Death 6 Interacting Protein (PDCD6IP))

Origin

Human

Source

Synthetic

Application

Blocking Peptide (BP), Western Blotting (WB)

Protein Region

C-Term

Sequence

YPGYCQMPMP MGYNPYAYGQ YNMPYPPVYH QSPGQAPYPG PQQPSYPFPQ

Characteristics

This is a synthetic peptide designed for use in combination with anti-PDC6I Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
Programmed Cell Death 6 Interacting Protein (PDCD6IP) (C-Term) peptide
PDCD6IP Reactivity: Human Host: Synthetic WB

Programmed Cell Death 6 Interacting Protein (PDCD6IP) (C-Term) peptide
PDCD6IP Reactivity: Human Host: Synthetic BP, WB

Programmed Cell Death 6 Interacting Protein (PDCD6IP) peptide
PDCD6IP Reactivity: Human Host: Synthetic BP, BI

Application Notes

Optimal working dilution should be determined by the investigator.

Restrictions

For Research Use only
Format

Lyophilized

Reconstitution

Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.

Storage

-20 °C

Storage Comment

For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
Target

ALIX (PDCD6IP) (Programmed Cell Death 6 Interacting Protein (PDCD6IP))

Background

This gene encodes a protein that functions within the ESCRT pathway in the abscission stage of cytokinesis, in intralumenal endosomal vesicle formation, and in enveloped virus budding. Studies using mouse cells have shown that overexpression of this protein can block apoptosis. In addition, the product of this gene binds to the product of the PDCD6 gene, a protein required for apoptosis, in a calcium-dependent manner. This gene product also binds to endophilins, proteins that regulate membrane shape during endocytosis. Overexpression of this gene product and endophilins results in cytoplasmic vacuolization, which may be partly responsible for the protection against cell death. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. Related pseudogenes have been identified on chromosome 15.

Alias Symbols: PDCD6IP,AIP1, ALIX, KIAA1375,

Protein Size: 868

Gene ID

10015

NCBI Accession

NP_037506

UniProt

Q8WUM4

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