Huntingtin Associated Protein 1 (HAP1) (Middle Region) Peptide
HAP1
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN5511253
Quick Overview for Huntingtin Associated Protein 1 (HAP1) (Middle Region) Peptide (ABIN5511253)
Target
HAP1
(Huntingtin Associated Protein 1 (HAP1))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- Middle Region
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Sequence
- VPLETLPGFQ ETLAEELRTS LRRMISDPVY FMERNYEMPR GDTSSLRYDF
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Characteristics
- This is a synthetic peptide designed for use in combination with HAP1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Huntingtin Associated Protein 1 (HAP1) peptide
HAP1 Reactivity: Mouse, Rat Host: Synthetic BP, Imm
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- HAP1 (Huntingtin Associated Protein 1 (HAP1))
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Background
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Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein that interacts with huntingtin, with two cytoskeletal proteins (dynactin and pericentriolar autoantigen protein 1), and with a hepatocyte growth factor-regulated tyrosine kinase substrate. The interactions with cytoskeletal proteins and a kinase substrate suggest a role for this protein in vesicular trafficking or organelle transport. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Alias Symbols: HLP, HAP2, HIP5, hHLP1
Protein Size: 671 -
Gene ID
- 9001
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NCBI Accession
- NM_001079870, NP_001073339
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UniProt
- P54257
Target
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