WNT1 Inducible Signaling Pathway Protein 1 (WISP1) (Middle Region) Peptide
WISP1
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN5511630
Quick Overview for WNT1 Inducible Signaling Pathway Protein 1 (WISP1) (Middle Region) Peptide (ABIN5511630)
Target
WISP1
(WNT1 Inducible Signaling Pathway Protein 1 (WISP1))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- Middle Region
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Sequence
- CEQWVCEDDA KRPRKTAPRD TGAFDAVGEV EAWHRNCIAY TSPWSPCSTS
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Characteristics
- This is a synthetic peptide designed for use in combination with anti- WISP1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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WNT1 Inducible Signaling Pathway Protein 1 (WISP1) peptide
WISP1 Reactivity: Human, Mouse, Rat Host: Synthetic BP, Imm
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- WISP1 (WNT1 Inducible Signaling Pathway Protein 1 (WISP1))
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Background
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This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. It is expressed at a high level in fibroblast cells, and overexpressed in colon tumors. The encoded protein binds to decorin and biglycan, two members of a family of small leucine-rich proteoglycans present in the extracellular matrix of connective tissue, and possibly prevents the inhibitory activity of decorin and biglycan in tumor cell proliferation. It also attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase. It is 83 % identical to the mouse protein at the amino acid level. Multiple alternatively spliced transcript variants have been identified.
Alias Symbols: CCN4, WISP1c, WISP1i, WISP1tc
Protein Size: 367 -
Gene ID
- 8840
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NCBI Accession
- NM_001204869, NP_001191798
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UniProt
- O95388
Target
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