Chemokine (C-X3-C Motif) Ligand 1 (CX3CL1) (Middle Region) Peptide
CX3CL1
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN5511691
Quick Overview for Chemokine (C-X3-C Motif) Ligand 1 (CX3CL1) (Middle Region) Peptide (ABIN5511691)
Target
CX3CL1
(Chemokine (C-X3-C Motif) Ligand 1 (CX3CL1))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- Middle Region
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Sequence
- VWGQGQSPRP ENSLEREEMG PVPAHTDAFQ DWGPGSMAHV SVVPVSSEGT
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Characteristics
- This is a synthetic peptide designed for use in combination with anti- CX3CL1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Chemokine (C-X3-C Motif) Ligand 1 (CX3CL1) peptide
CX3CL1 Reactivity: Human, Mouse, Rat Host: Synthetic BP, Imm
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- CX3CL1 (Chemokine (C-X3-C Motif) Ligand 1 (CX3CL1))
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Background
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Acts as a ligand for both CX3CL1 and integrins. Binds to CX3CR1. Binds to integrins ITGAV:ITGB3 and ITGA4:ITGB1. Can activate integrins in both a CX3CR1-dependent and CX3CR1-independent manner. In the presence of CX3CR1, activates integrins by binding to the classical ligand-binding site (site 1) in integrins. In the absence of CX3CR1, binds to a second site (site 2) in integrins which is distinct from site 1 and enhances the binding of other integrin ligands to site 1. The soluble form is chemotactic for T-cells and monocytes and not for neutrophils. The membrane-bound form promotes adhesion of those leukocytes to endothelial cells. May play a role in regulating leukocyte adhesion and migration processes at the endothelium.
Alias Symbols: NTN, NTT, CXC3, CXC3C, SCYD1, ABCD-3, C3Xkine, fractalkine, neurotactin
Protein Size: 397 -
Gene ID
- 6376
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NCBI Accession
- NM_001304392, NP_002987
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UniProt
- P78423
Target
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