Basic Leucine Zipper Transcription Factor, ATF-Like 2 (BATF2) (N-Term) Peptide
BATF2
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN5512169
Quick Overview for Basic Leucine Zipper Transcription Factor, ATF-Like 2 (BATF2) (N-Term) Peptide (ABIN5512169)
Target
BATF2
(Basic Leucine Zipper Transcription Factor, ATF-Like 2 (BATF2))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- N-Term
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Sequence
- CGGNGLLTQT DPKEQQRQLK KQKNRAAAQR SRQKHTDKAD ALHQQHESLE
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-BATF2 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- BATF2 (Basic Leucine Zipper Transcription Factor, ATF-Like 2 (BATF2))
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Background
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BATF2 is a AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system. Following infection, it participates in the differentiation of CD8(+) thymic conventional dendritic cells in the immune system. It acts via the formation of a heterodimer with JUN family proteins that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3' and regulates expression of target genes (By similarity). It selectively suppresses CYR61/CCN1 transcription and hence blocks the downstream cell proliferation signals produced by CYR61 and inhibits CYR61-induced anchorage-independent growth and invasion in several cancer types, such as breast cancer, malignant glioma and metastatic melanoma. It possibly acts by interfering with AP-1 binding to CYR61 promoter.
Alias Symbols: BATF2,
Protein Size: 274 -
Gene ID
- 116071
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UniProt
- Q8N1L9
Target
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