Cyclin D Binding Myb-Like Transcription Factor 1 (DMTF1) (Middle Region) Peptide
DMTF1
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN5512274
Quick Overview for Cyclin D Binding Myb-Like Transcription Factor 1 (DMTF1) (Middle Region) Peptide (ABIN5512274)
Target
DMP1 (DMTF1)
(Cyclin D Binding Myb-Like Transcription Factor 1 (DMTF1))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- Middle Region
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Sequence
- FSRSTGKGGD DKDDDEDDSG DDTFGDDDSG PGPKDRQEGG NSRLGSDEDS
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Characteristics
- This is a synthetic peptide designed for use in combination with anti- DMP1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Cyclin D Binding Myb-Like Transcription Factor 1 (DMTF1) peptide
DMTF1 Reactivity: Human Host: Synthetic BP, Imm
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- DMP1 (DMTF1) (Cyclin D Binding Myb-Like Transcription Factor 1 (DMTF1))
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Background
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Dentin matrix acidic phosphoprotein is an extracellular matrix protein and a member of the small integrin binding ligand N-linked glycoprotein family. This protein, which is critical for proper mineralization of bone and dentin, is present in diverse cells of bone and tooth tissues. The protein contains a large number of acidic domains, multiple phosphorylation sites, a functional arg-gly-asp cell attachment sequence, and a DNA binding domain. In undifferentiated osteoblasts it is primarily a nuclear protein that regulates the expression of osteoblast-specific genes. During osteoblast maturation the protein becomes phosphorylated and is exported to the extracellular matrix, where it orchestrates mineralized matrix formation. Mutations in the gene are known to cause autosomal recessive hypophosphatemia, a disease that manifests as rickets and osteomalacia. The gene structure is conserved in mammals. Two transcript variants encoding different isoforms have been described for this gene.
Alias Symbols: ARHP, ARHR, DMP-1
Protein Size: 497 -
Gene ID
- 1758
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NCBI Accession
- NM_001079911, NP_001073380
Target
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