Histamine N-Methyltransferase (HNMT) (C-Term) Peptide
HNMT
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN5512367
Quick Overview for Histamine N-Methyltransferase (HNMT) (C-Term) Peptide (ABIN5512367)
Target
HNMT
(Histamine N-Methyltransferase (HNMT))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- C-Term
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Sequence
- SGWDKLWKKY GSRFPQDDLC QYITSDDLTQ MLDNLGLKYE CYDLLSTMDI
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-HNMT Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- HNMT (Histamine N-Methyltransferase (HNMT))
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Background
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In mammals, histamine is metabolized by two major pathways: N(tau)-methylation via histamine N-methyltransferase and oxidative deamination via diamine oxidase. This gene encodes the first enzyme which is found in the cytosol and uses S-adenosyl-L-methionine as the methyl donor. In the mammalian brain, the neurotransmitter activity of histamine is controlled by N(tau)-methylation as diamine oxidase is not found in the central nervous system. A common genetic polymorphism affects the activity levels of this gene product in red blood cells. Multiple alternatively spliced transcript variants that encode different proteins have been found for this gene.
Alias Symbols: HNMT,
Protein Size: 292 -
Gene ID
- 3176
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NCBI Accession
- NP_008826
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UniProt
- P50135
Target
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