Stratifin (SFN) (N-Term) Peptide
SFN
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN5512711
Quick Overview for Stratifin (SFN) (N-Term) Peptide (ABIN5512711)
Target
14-3-3 sigma/SFN (SFN)
(Stratifin (SFN))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- N-Term
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Sequence
- IEQKSNEEGS EEKGPEVREY REKVETELQG VCDTVLGLLD SHLIKEAGDA
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-SFN Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- 14-3-3 sigma/SFN (SFN) (Stratifin (SFN))
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Background
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SFN is a p53-regulated inhibitor of G2/M progression. It is an adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. It binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. It may also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53.
Alias Symbols: SFN,HME1,
Protein Size: 248 -
Gene ID
- 2810
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NCBI Accession
- NP_006133
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UniProt
- P31947
Target
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