B-Cell Linker (BLNK) (N-Term) Peptide
BLNK
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN5512763
Quick Overview for B-Cell Linker (BLNK) (N-Term) Peptide (ABIN5512763)
Target
B-Cell Linker (BLNK)
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- N-Term
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Sequence
- ADEEEQWSDD FDSDYENPDE HSDSEMYVMP AEENADDSYE PPPVEQETRP
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Characteristics
- This is a synthetic peptide designed for use in combination with anti- BLNK Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- B-Cell Linker (BLNK)
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Background
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This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants have been found for this gene.
Alias Symbols: bca, AGM4, BASH, LY57, SLP65, BLNK-S, SLP-65
Protein Size: 456 -
Gene ID
- 29760
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NCBI Accession
- NM_001114094, NP_001107566
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UniProt
- Q8WV28
Target
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