Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3) (C-Term) Peptide
ERBB3
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN5512987
Quick Overview for Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3) (C-Term) Peptide (ABIN5512987)
Target
ERBB3
(Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- C-Term
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Sequence
- SASLGSTQSC PLHPVPIMPT AGTTPDEDYE YMNRQRDGGG PGGDYAAMGA
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Characteristics
- This is a synthetic peptide designed for use in combination with anti- ERBB3 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- ERBB3 (Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3))
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Background
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This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized.
Alias Symbols: HER3, LCCS2, ErbB-3, c-erbB3, erbB3-S, MDA-BF-1, c-erbB-3, p180-ErbB3, p45-sErbB3, p85-sErbB3
Protein Size: 699 -
Gene ID
- 2065
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NCBI Accession
- NM_001005915, NP_001005915
Target
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