Pyruvate Dehydrogenase (Lipoamide) alpha 1 (PDHA1) (Middle Region) Peptide
PDHA1
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN5513490
Quick Overview for Pyruvate Dehydrogenase (Lipoamide) alpha 1 (PDHA1) (Middle Region) Peptide (ABIN5513490)
Target
PDHA1
(Pyruvate Dehydrogenase (Lipoamide) alpha 1 (PDHA1))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- Middle Region
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Sequence
- AASTDYYKRG DFIPGLRVDG MDILCVREAT RFAAAYCRSG KGPILMELQT
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Characteristics
- This is a synthetic peptide designed for use in combination with anti-PDHA1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- PDHA1 (Pyruvate Dehydrogenase (Lipoamide) alpha 1 (PDHA1))
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Background
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The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle. The PDH complex is composed of multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). The E1 enzyme is a heterotetramer of two alpha and two beta subunits. This gene encodes the E1 alpha 1 subunit containing the E1 active site, and plays a key role in the function of the PDH complex. Mutations in this gene are associated with pyruvate dehydrogenase E1-alpha deficiency and X-linked Leigh syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: PDHA, PDHAD, PHE1A, PDHCE1A
Protein Size: 390 -
Gene ID
- 5160
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NCBI Accession
- NM_000284, NP_000275
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UniProt
- P08559
Target
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