R-Spondin 1 (RSPO1) (C-Term) Peptide
RSPO1
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all RSPO1 products
- RSPO1 (R-Spondin 1 (RSPO1))
- Protein Region
- C-Term
- Origin
- Human
- Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- RCTVRRVPCP EGQKRRKGGQ GRRENANRNL ARKESKEAGA GSRRRKGQQQ
- Characteristics
- This is a synthetic peptide designed for use in combination with anti- RSPO1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- RSPO1 (R-Spondin 1 (RSPO1))
- Background
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This gene encodes a secreted activator protein with two cysteine-rich, furin-like domains and one thrombospondin type 1 domain. The encoded protein is a ligand for leucine-rich repeat-containing G-protein coupled receptors (LGR proteins) and positively regulates the Wnt signaling pathway. In mice, the protein induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects. Alternative splicing results in multiple transcript variants.
Alias Symbols: RSPO, CRISTIN3
Protein Size: 236 - Gene ID
- 284654
- NCBI Accession
- NM_001242909, NP_001229838
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