DNA Fragmentation Factor, 45kDa, alpha Polypeptide (DFFA) (Middle Region) Peptide
DFFA
Reactivity: Human
Host: Synthetic
WB
Quick Overview for DNA Fragmentation Factor, 45kDa, alpha Polypeptide (DFFA) (Middle Region) Peptide (ABIN5518125)
Target
DFFA
(DNA Fragmentation Factor, 45kDa, alpha Polypeptide (DFFA))
Origin
Human
Source
Synthetic
Application
Western Blotting (WB)
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Protein Region
- Middle Region
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Sequence
- DYFLCLPSNT KFVALASNEK WAYNNSDGGT AWISQESFDV DETDSGAGLK
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- DFFA (DNA Fragmentation Factor, 45kDa, alpha Polypeptide (DFFA))
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Background
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Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Alias Symbols: DFF1, ICAD, DFF-45,
Protein Size: 167 -
Gene ID
- 1676
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NCBI Accession
- NM_004401, NP_004392
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UniProt
- O00273
Target
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