Mitogen-Activated Protein Kinase 1 (MAPK1) (Middle Region) Peptide
MAPK1
Reactivity: Human
Host: Synthetic
WB
Catalog No. ABIN5518171
Quick Overview for Mitogen-Activated Protein Kinase 1 (MAPK1) (Middle Region) Peptide (ABIN5518171)
Target
ERK2 (MAPK1)
(Mitogen-Activated Protein Kinase 1 (MAPK1))
Origin
Human
Source
Synthetic
Application
Western Blotting (WB)
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Protein Region
- Middle Region
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Sequence
- HKNKVPWNRL FPNADSKALD LLDKMLTFNP HKRIEVEQAL AHPYLEQYYD
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- ERK2 (MAPK1) (Mitogen-Activated Protein Kinase 1 (MAPK1))
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Background
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This gene encodes a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. One study also suggests that this protein acts as a transcriptional repressor independent of its kinase activity. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene.
Alias Symbols: ERK, p38, p40, p41, ERK2, ERT1, ERK-2, MAPK2, PRKM1, PRKM2, P42MAPK, p41mapk, p42-MAPK
Protein Size: 167 -
Gene ID
- 5594
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NCBI Accession
- NM_002745, NP_002736
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UniProt
- P28482
Target
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