Programmed Cell Death 6 Interacting Protein (PDCD6IP) (C-Term) Peptide
PDCD6IP
Reactivity: Human
Host: Synthetic
WB
-
- Target See all ALIX (PDCD6IP) products
- ALIX (PDCD6IP) (Programmed Cell Death 6 Interacting Protein (PDCD6IP))
- Protein Region
- C-Term
- Origin
- Human
-
Source
- Synthetic
- Application
- Western Blotting (WB)
- Sequence
- QMPMPMGYNP YAYGQYNMPY PPVYHQSPGQ APYPGPQQPS YPFPQPPQQS
-
-
- Restrictions
- For Research Use only
-
- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
-
- Target
- ALIX (PDCD6IP) (Programmed Cell Death 6 Interacting Protein (PDCD6IP))
- Background
-
This gene encodes a protein that functions within the ESCRT pathway in the abscission stage of cytokinesis, in intralumenal endosomal vesicle formation, and in enveloped virus budding. Studies using mouse cells have shown that overexpression of this protein can block apoptosis. In addition, the product of this gene binds to the product of the PDCD6 gene, a protein required for apoptosis, in a calcium-dependent manner. This gene product also binds to endophilins, proteins that regulate membrane shape during endocytosis. Overexpression of this gene product and endophilins results in cytoplasmic vacuolization, which may be partly responsible for the protection against cell death. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. Related pseudogenes have been identified on chromosome 15.
Alias Symbols: AIP1, ALIX, HP95, DRIP4
Protein Size: 167 - Gene ID
- 10015
- NCBI Accession
- NM_001162429, NP_001155901
- UniProt
- Q8WUM4
-
You are here:
