Hemoglobin A (HbA) Peptide
Quick Overview for Hemoglobin A (HbA) Peptide (ABIN5624563)
Target
Source
Application
-
-
Peptide Type
- Synthetic
-
Supplier Product No.
- 000-001-gs4
-
Supplier
- Rockland
-
Purpose
- Hemoglobin A (beta chain) Control Peptide
-
Characteristics
- Hbβ Control Peptide, Hemoglobin beta subunit, HBB, Sickle Cell Disease (SCD)
-
Purification
- Greater than 95% specific peptide
-
Purity
- Greater than 95% specific peptide
-
-
-
Application Notes
- Optional[Flow Cytometry Dilution]: Hemoglobin A (beta chain) peptide can be used as a control with the HbA antibody. Control peptide should be used at 1.0 μg per 1.0 μL of antiserum in per assay.
-
Restrictions
- For Research Use only
-
-
-
Format
- Lyophilized
-
Reconstitution
-
Reconstitution Buffer: Restore with deionized water (or equivalent)
Reconstitution Volume: 50μL
-
Concentration
- 1.0 mg/mL
-
Buffer
-
Buffer: None
Stabilizer: None
Preservative: None -
Preservative
- Without preservative
-
Storage
- 4 °C,-20 °C
-
Storage Comment
- Store vial at 2-8 °C prior to opening. Aliquot contents and freeze at -20 °C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. Dilute only prior to immediate use.
-
Expiry Date
- 6 months
-
-
- Hemoglobin A (HbA)
-
Background
-
Synonyms: Hbβ Control Peptide, Hemoglobin beta subunit, HBB, Sickle Cell Disease (SCD)
Background: HbA peptide correspond to the hemoglobin beta subunit wild type variant A isoform. Functional adult hemoglobin (Hb) is a hetero tetramer composed of 2 alpha and 2 beta subunits (α2β2). Common isoform variants of hemoglobin include HbA, HbS, HbC, HbF, and HbA2. Sickle cell disease (SCD), thalassemias and hemoglobinopathies occur when aberrant forms of hemoglobin are expressed in children and adults. Globin gene mutations affect the structure and expression levels of Hb. Sickle cell disease and the more benign sickle cell trait are observed in more than 100 million people globally. Perhaps the most significant mutation is the E6V in the beta subunit and the cause of SCD, but other relevant isoforms of Hb are observed. HbA peptide can be used as a control with the HbA antibody. This peptide is ideal for investigators involved in Cardiovascular and developmental biology research.
-
Gene ID
- 3043
-
NCBI Accession
- NP_000509
-
UniProt
- P68871
Target
-
