V-Akt Murine Thymoma Viral Oncogene Homolog 1 (AKT1) (N-Term) Peptide
AKT1
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN5671417
Quick Overview for V-Akt Murine Thymoma Viral Oncogene Homolog 1 (AKT1) (N-Term) Peptide (ABIN5671417)
Target
AKT1
(V-Akt Murine Thymoma Viral Oncogene Homolog 1 (AKT1))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- N-Term
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Sequence
- RGEYIKTWRP RYFLLKNDGT FIGYKERPQD VDQREAPLNN FSVAQCQLMK
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Characteristics
- This is a synthetic peptide designed for use in combination with anti- AKT1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- AKT1 (V-Akt Murine Thymoma Viral Oncogene Homolog 1 (AKT1))
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Background
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The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene.
Alias Symbols: AKT, PKB, RAC, CWS6, PRKBA, PKB-ALPHA, RAC-ALPHA
Protein Size: 480 -
Gene ID
- 207
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NCBI Accession
- NM_001014431, NP_001014431
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UniProt
- P31749
Target
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