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V-Akt Murine Thymoma Viral Oncogene Homolog 1 (AKT1) (N-Term) Peptide

AKT1 Reactivity: Human Host: Synthetic BP, WB
Catalog No. ABIN5671417
  • Target See all AKT1 products
    AKT1 (V-Akt Murine Thymoma Viral Oncogene Homolog 1 (AKT1))
    Protein Region
    N-Term
    Origin
    Human
    Source
    • 26
    Synthetic
    Application
    Blocking Peptide (BP), Western Blotting (WB)
    Sequence
    RGEYIKTWRP RYFLLKNDGT FIGYKERPQD VDQREAPLNN FSVAQCQLMK
    Characteristics
    This is a synthetic peptide designed for use in combination with anti- AKT1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
    Storage
    -20 °C
    Storage Comment
    For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
  • Target
    AKT1 (V-Akt Murine Thymoma Viral Oncogene Homolog 1 (AKT1))
    Background
    The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene.

    Alias Symbols: AKT, PKB, RAC, CWS6, PRKBA, PKB-ALPHA, RAC-ALPHA

    Protein Size: 480
    Gene ID
    207
    NCBI Accession
    NM_001014431, NP_001014431
    UniProt
    P31749
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