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MutS Homolog 6 (E. Coli) (MSH6) (Middle Region) Peptide

MSH6 Reactivity: Human Host: Synthetic BP, WB

Catalog No. ABIN5671696

Quick Overview for MutS Homolog 6 (E. Coli) (MSH6) (Middle Region) Peptide (ABIN5671696)

Target

MSH6 (MutS Homolog 6 (E. Coli) (MSH6))

Origin

Human

Source

Synthetic

Application

Blocking Peptide (BP), Western Blotting (WB)

Protein Region

Middle Region

Sequence

MVVPDKISEV VELLKKLPDL ERLLSKIHNV GSPLKSQNHP DSRAIMYEET

Characteristics

This is a synthetic peptide designed for use in combination with anti- MSH6 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
MutS Homolog 6 (E. Coli) (MSH6) peptide
MSH6 Reactivity: Mammalian Host: Synthetic BP, WB, IHC

MutS Homolog 6 (E. Coli) (MSH6) (N-Term) peptide
MSH6 Reactivity: Human Host: Synthetic BP, WB, IHC

MutS Homolog 6 (E. Coli) (MSH6) peptide
MSH6 Reactivity: Human, Monkey Host: Synthetic BP

Application Notes

Optimal working dilution should be determined by the investigator.

Restrictions

For Research Use only
Format

Lyophilized

Reconstitution

Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.

Storage

-20 °C

Storage Comment

For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
Target

MSH6 (MutS Homolog 6 (E. Coli) (MSH6))

Background

This gene encodes a member of the DNA mismatch repair MutS family. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides prior to their repair. A highly conserved region of approximately 150 aa, called the Walker-A adenine nucleotide binding motif, exists in MutS homologs. The encoded protein heterodimerizes with MSH2 to form a mismatch recognition complex that functions as a bidirectional molecular switch that exchanges ADP and ATP as DNA mismatches are bound and dissociated. Mutations in this gene may be associated with hereditary nonpolyposis colon cancer, colorectal cancer, and endometrial cancer. Transcripts variants encoding different isoforms have been described.

Alias Symbols: GTBP, HSAP, p160, GTMBP, HNPCC5

Protein Size: 1360

Gene ID

2956

NCBI Accession

NM_000179, NP_000170

UniProt

P52701

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