Protein Kinase A, alpha (PRKACA) (N-Term) Peptide
PRKACA
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN5672619
$160.46
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100 μg
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Quick Overview for Protein Kinase A, alpha (PRKACA) (N-Term) Peptide (ABIN5672619)
Target
PRKACA
(Protein Kinase A, alpha (PRKACA))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- N-Term
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Sequence
- FLKKWESPAQ NTAHLDQFER IKTLGTGSFG RVMLVKHKET GNHYAMKILD
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Characteristics
- This is a synthetic peptide designed for use in combination with anti- PRKACA Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- PRKACA (Protein Kinase A, alpha (PRKACA))
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Background
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This gene encodes one of the catalytic subunits of protein kinase A, which exists as a tetrameric holoenzyme with two regulatory subunits and two catalytic subunits, in its inactive form. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. cAMP-dependent phosphorylation of proteins by protein kinase A is important to many cellular processes, including differentiation, proliferation, and apoptosis. Constitutive activation of this gene caused either by somatic mutations, or genomic duplications of regions that include this gene, have been associated with hyperplasias and adenomas of the adrenal cortex and are linked to corticotropin-independent Cushing's syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. Tissue-specific isoforms that differ at the N-terminus have been described, and these isoforms may differ in the post-translational modifications that occur at the N-terminus of some isoforms.
Alias Symbols: PKACA, PPNAD4
Protein Size: 351 -
Gene ID
- 5566
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NCBI Accession
- NM_001304349, NP_001291278
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UniProt
- P17612
Target
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