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Cell Adhesion Molecule 1 (CADM1) (C-Term) Peptide

CADM1 Reactivity: Human Host: Synthetic BP, WB
Catalog No. ABIN5672782
  • Target See all CADM1 products
    CADM1 (Cell Adhesion Molecule 1 (CADM1))
    Protein Region
    C-Term
    Origin
    Human
    Source
    • 7
    Synthetic
    Application
    Blocking Peptide (BP), Western Blotting (WB)
    Sequence
    LLIILGRYFA RHKGTYFTHE AKGADDAADA DTAIINAEGG QNNSEEKKEY
    Characteristics
    This is a synthetic peptide designed for use in combination with anti- CADM1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
    Storage
    -20 °C
    Storage Comment
    For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
  • Target
    CADM1 (Cell Adhesion Molecule 1 (CADM1))
    Background
    Mediates homophilic cell-cell adhesion in a Ca2+-independent manner. Also mediates heterophilic cell-cell adhesion with CADM3 and NECTIN3 in a Ca2+-independent manner. Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. May contribute to the less invasive phenotypes of lepidic growth tumor cells. In mast cells, may mediate attachment to and promote communication with nerves. CADM1, together with MITF, is essential for development and survival of mast cells in vivo. Acts as a synaptic cell adhesion molecule and plays a role in the formation of dendritic spines and in synapse assembly. May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa.

    Alias Symbols: BL2, ST17, IGSF4, NECL2, RA175, TSLC1, IGSF4A, Necl-2, SYNCAM, sgIGSF, sTSLC-1, synCAM1

    Protein Size: 414
    Gene ID
    23705
    NCBI Accession
    NM_001098517, NP_001091987
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