Itchy E3 Ubiquitin Protein Ligase Homolog (ITCH) (Middle Region) Peptide
ITCH
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all ITCH products
- ITCH (Itchy E3 Ubiquitin Protein Ligase Homolog (ITCH))
- Protein Region
- Middle Region
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- KPSRPPRPSR PPPPTPRRPA SVNGSPSATS ESDGSSTGSL PPTNTNTNTS
- Characteristics
- This is a synthetic peptide designed for use in combination with anti- ITCH Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- ITCH (Itchy E3 Ubiquitin Protein Ligase Homolog (ITCH))
- Background
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This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein plays a role in multiple cellular processes including erythroid and lymphoid cell differentiation and the regulation of immune responses. Mutations in this gene are a cause of syndromic multisystem autoimmune disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Alias Symbols: AIF4, AIP4, ADMFD, NAPP1
Protein Size: 752 - Gene ID
- 83737
- NCBI Accession
- NM_001257137, NP_001244066
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