Itchy E3 Ubiquitin Protein Ligase Homolog (ITCH) (Middle Region) Peptide
ITCH
Reactivity: Human
Host: Synthetic
BP, WB
Catalog No. ABIN5672845
Quick Overview for Itchy E3 Ubiquitin Protein Ligase Homolog (ITCH) (Middle Region) Peptide (ABIN5672845)
Target
ITCH
(Itchy E3 Ubiquitin Protein Ligase Homolog (ITCH))
Origin
Human
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- Middle Region
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Sequence
- KPSRPPRPSR PPPPTPRRPA SVNGSPSATS ESDGSSTGSL PPTNTNTNTS
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Characteristics
- This is a synthetic peptide designed for use in combination with anti- ITCH Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Application Notes
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Storage
- -20 °C
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Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- ITCH (Itchy E3 Ubiquitin Protein Ligase Homolog (ITCH))
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Background
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This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein plays a role in multiple cellular processes including erythroid and lymphoid cell differentiation and the regulation of immune responses. Mutations in this gene are a cause of syndromic multisystem autoimmune disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Alias Symbols: AIF4, AIP4, ADMFD, NAPP1
Protein Size: 752 -
Gene ID
- 83737
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NCBI Accession
- NM_001257137, NP_001244066
Target
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